Nature Communications (Jan 2020)
Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
- Maria C. Ferreira dos Santos,
- Cole P. Anderson,
- Susanne Neschen,
- Kimberly B. Zumbrennen-Bullough,
- Steven J. Romney,
- Melanie Kahle-Stephan,
- Birgit Rathkolb,
- Valerie Gailus-Durner,
- Helmut Fuchs,
- Eckhard Wolf,
- Jan Rozman,
- Martin Hrabe de Angelis,
- Weiling Maggie Cai,
- Malini Rajan,
- Jennifer Hu,
- Peter C. Dedon,
- Elizabeth A. Leibold
Affiliations
- Maria C. Ferreira dos Santos
- Department of Medicine, Division of Hematology, University of Utah
- Cole P. Anderson
- Molecular Medicine Program, University of Utah
- Susanne Neschen
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München
- Kimberly B. Zumbrennen-Bullough
- Molecular Medicine Program, University of Utah
- Steven J. Romney
- Department of Medicine, Division of Hematology, University of Utah
- Melanie Kahle-Stephan
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München
- Birgit Rathkolb
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München
- Valerie Gailus-Durner
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München
- Helmut Fuchs
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München
- Eckhard Wolf
- Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universität München
- Jan Rozman
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München
- Martin Hrabe de Angelis
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München
- Weiling Maggie Cai
- Department of Microbiology, National University of Singapore
- Malini Rajan
- Department of Medicine, Division of Hematology, University of Utah
- Jennifer Hu
- Department of Chemistry, Massachusetts Institute of Technology
- Peter C. Dedon
- Antimicrobial Resistance Interdisciplinary Research Group (IRG), Singapore-MIT Alliance for Research and Technology, 1 CREATE Way
- Elizabeth A. Leibold
- Department of Medicine, Division of Hematology, University of Utah
- DOI
- https://doi.org/10.1038/s41467-019-14004-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Iron metabolism is linked to type 2 diabetes. Here the authors describe a mechanism through which cellular iron deficiency caused by loss of Irp2 impairs Cdkal1 function, resulting in inaccurate proinsulin translation, impaired proinsulin processing and reduced insulin secretion.
