Nature Communications (Jun 2020)
A SAM-I riboswitch with the ability to sense and respond to uncharged initiator tRNA
- Dong-Jie Tang,
- Xinyu Du,
- Qiang Shi,
- Jian-Ling Zhang,
- Yuan-Ping He,
- Yan-Miao Chen,
- Zhenhua Ming,
- Dan Wang,
- Wan-Ying Zhong,
- Yu-Wei Liang,
- Jin-Yang Liu,
- Jian-Ming Huang,
- Yun-Shi Zhong,
- Shi-Qi An,
- Hongzhou Gu,
- Ji-Liang Tang
Affiliations
- Dong-Jie Tang
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University
- Xinyu Du
- Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University
- Qiang Shi
- Endoscopy Center, Zhongshan Hospital of Fudan University
- Jian-Ling Zhang
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University
- Yuan-Ping He
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University
- Yan-Miao Chen
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University
- Zhenhua Ming
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University
- Dan Wang
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University
- Wan-Ying Zhong
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University
- Yu-Wei Liang
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University
- Jin-Yang Liu
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University
- Jian-Ming Huang
- Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center
- Yun-Shi Zhong
- Endoscopy Center, Zhongshan Hospital of Fudan University
- Shi-Qi An
- National Biofilms Innovation Centre (NBIC), Biological Sciences, University of Southampton
- Hongzhou Gu
- Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University
- Ji-Liang Tang
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University
- DOI
- https://doi.org/10.1038/s41467-020-16417-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Riboswitches consist of an aptamer domain and expression platform, which senses a signal and regulates gene expression, respectively. Here the authors show that the expression platform of a SAM-I riboswitch from the Gram-negative bacteria can sense and bind uncharged an initiator Met tRNA to control the met operon.
