Extracellular DNA released by glycine-auxotrophic Staphylococcus epidermidis small colony variant facilitates catheter-related infections

Junlan Liu; Zhen Shen; Jin Tang; Qian Huang; Ying Jian; Yao Liu; Yanan Wang; Xiaowei Ma; Qian Liu; Lei He; Min Li

doi:10.1038/s42003-021-02423-4

Communications Biology (Jul 2021)

Extracellular DNA released by glycine-auxotrophic Staphylococcus epidermidis small colony variant facilitates catheter-related infections

Junlan Liu,
Zhen Shen,
Jin Tang,
Qian Huang,
Ying Jian,
Yao Liu,
Yanan Wang,
Xiaowei Ma,
Qian Liu,
Lei He,
Min Li

Affiliations

Junlan Liu: Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Zhen Shen: Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Jin Tang: Department of Laboratory Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Qian Huang: Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Ying Jian: Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Yao Liu: Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Yanan Wang: Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Xiaowei Ma: Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Qian Liu: Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Lei He: Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Min Li: Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s42003-021-02423-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

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Liu et al. investigate the mechanism for small colony variant (SCV) formation in Staphylococcus epidermidis and following genomic and metabolomic analysis, implicate a frame-shift mutation in glycine production as a potential cause of SCV formation. The authors also examine the effect of eDNA production and biofilm formation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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