MRI detection of mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE) on T1WI-CHESS

Elly Arizono; Zen-ichi Tanei; Keiya Iijima; Yukio Kimura; Yoko Shigemoto; Hiroyuki Maki; Midori Kusama; Kumiko Murayama; Masaki Iwasaki; Takashi Saito; Yuko Saito; Kazuhiro Saito; Noriko Sato

Epilepsy & Behavior Reports (Jan 2024)

MRI detection of mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE) on T1WI-CHESS

Elly Arizono,
Zen-ichi Tanei,
Keiya Iijima,
Yukio Kimura,
Yoko Shigemoto,
Hiroyuki Maki,
Midori Kusama,
Kumiko Murayama,
Masaki Iwasaki,
Takashi Saito,
Yuko Saito,
Kazuhiro Saito,
Noriko Sato

Affiliations

Elly Arizono: Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan; Department of Radiology, Tokyo Medical University, School of Medicine, Tokyo, Japan
Zen-ichi Tanei: Department of Cancer Pathology, Hokkaido University, Faculty of Medicine, Hokkaido, Japan
Keiya Iijima: Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
Yukio Kimura: Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
Yoko Shigemoto: Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
Hiroyuki Maki: Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
Midori Kusama: Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
Kumiko Murayama: Department of Genome Medicine Development, Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan
Masaki Iwasaki: Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
Takashi Saito: Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan
Yuko Saito: Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Kazuhiro Saito: Department of Radiology, Tokyo Medical University, School of Medicine, Tokyo, Japan
Noriko Sato: Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan; Corresponding author at: Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.

Journal volume & issue: Vol. 26
p. 100674

Abstract

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Mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE) is a recently proposed epileptogenic entity that is difficult to detect on MRI. We present a case of MOGHE that was successfully detected on T1WI-chemical shift-selective saturation (CHESS) MRI. The clinical presentation, MRI including T1WI-CHESS, functional images, and pathology findings of a 14-year-old Japanese girl diagnosed with MOGHE are described. T1WI-CHESS revealed an abnormal high signal along the affected lesion, whereas the findings shown by the other MR sequences were less obvious; interictal fluorodeoxyglucose-positron emission tomography indicated slightly decreased accumulation in the lesion, and subtraction ictal single photon emission computed tomography co-registered to MRI showed an increased blood flow. Together these observations suggest that T1WI-CHESS may be a useful MR sequence for detecting the lesions in patients with MOGHE.

Published in Epilepsy & Behavior Reports

ISSN: 2589-9864 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system; Science: Physiology: Neurophysiology and neuropsychology
Website: https://www.journals.elsevier.com/epilepsy-and-behavior-reports

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