F1000Research (Oct 2016)

Bacteriocin production: a relatively unharnessed probiotic trait? [version 1; referees: 2 approved]

  • James W. Hegarty,
  • Caitriona M. Guinane,
  • R. Paul Ross,
  • Colin Hill,
  • Paul D. Cotter

DOI
https://doi.org/10.12688/f1000research.9615.1
Journal volume & issue
Vol. 5

Abstract

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Probiotics are “live microorganisms which, when consumed in adequate amounts, confer a health benefit to the host”. A number of attributes are highly sought after among these microorganisms, including immunomodulation, epithelial barrier maintenance, competitive exclusion, production of short-chain fatty acids, and bile salt metabolism. Bacteriocin production is also generally regarded as a probiotic trait, but it can be argued that, in contrast to other traits, it is often considered a feature that is desirable, rather than a key probiotic trait. As such, the true potential of these antimicrobials has yet to be realised.

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