Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection

Nature Communications. 2018;9(1):1-11 DOI 10.1038/s41467-018-06103-6

 

Journal Homepage

Journal Title: Nature Communications

ISSN: 2041-1723 (Online)

Publisher: Nature Publishing Group

LCC Subject Category: Science

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Tao Zuo (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)
Sunny H. Wong (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)
Chun Pan Cheung (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)
Kelvin Lam (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)
Rashid Lui (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)
Kitty Cheung (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)
Fen Zhang (Shenzhen Research Institute, The Chinese University of Hong Kong)
Whitney Tang (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)
Jessica Y. L. Ching (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)
Justin C. Y. Wu (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)
Paul K. S. Chan (Center for Gut Microbiota Research, The Chinese University of Hong Kong)
Joseph J. Y. Sung (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)
Jun Yu (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)
Francis K. L. Chan (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)
Siew C. Ng (Department of Medicine and Therapeutics, The Chinese University of Hong Kong)

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 28 weeks

 

Abstract | Full Text

Fecal microbiota transplantation (FMT) is effective in treating recurrent Clostridium difficile infection (CDI). Here, the authors show that the composition of the gut fungal microbiota of donors and recipients, and especially the abundance of Candida, correlates with FMT outcome in CDI patients.