Integrated multi-omics reveal important roles of gut contents in intestinal ischemia–reperfusion induced injuries in rats

Die Dai; Fandie Dai; Jingchao Chen; Menglu Jin; Mingyue Li; Desheng Hu; Zhi Liu; Zunjian Zhang; Fengguo Xu; Wei-Hua Chen

doi:10.1038/s42003-022-03887-8

Communications Biology (Sep 2022)

Integrated multi-omics reveal important roles of gut contents in intestinal ischemia–reperfusion induced injuries in rats

Die Dai,
Fandie Dai,
Jingchao Chen,
Menglu Jin,
Mingyue Li,
Desheng Hu,
Zhi Liu,
Zunjian Zhang,
Fengguo Xu,
Wei-Hua Chen

Affiliations

Die Dai: Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-Imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology
Fandie Dai: Applied Psychology Institution, China University of Geosciences
Jingchao Chen: Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-Imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology
Menglu Jin: College of Life Science, Henan Normal University
Mingyue Li: Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Desheng Hu: Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Zhi Liu: Department of Biotechnology, Huazhong University of Science and Technology, College of Life Sciences and Technology
Zunjian Zhang: Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University
Fengguo Xu: Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University
Wei-Hua Chen: Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-Imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology

DOI: https://doi.org/10.1038/s42003-022-03887-8
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

Read online

Die Dai et al. evaluate changes in the metabolomic and gut microbiome in response to experimental intestinal ischemia reperfusion (IIR) injury in rats. Their results provide further insight into how gut contents contribute to widespread injury in IIR patients.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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