Nature Communications (May 2022)
HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins
- Ulrike Zinnall,
- Miha Milek,
- Igor Minia,
- Carlos H. Vieira-Vieira,
- Simon Müller,
- Guido Mastrobuoni,
- Orsalia-Georgia Hazapis,
- Simone Del Giudice,
- David Schwefel,
- Nadine Bley,
- Franka Voigt,
- Jeffrey A. Chao,
- Stefan Kempa,
- Stefan Hüttelmaier,
- Matthias Selbach,
- Markus Landthaler
Affiliations
- Ulrike Zinnall
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology
- Miha Milek
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology
- Igor Minia
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology
- Carlos H. Vieira-Vieira
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology
- Simon Müller
- Institute of Molecular Medicine, Medical Faculty, Martin Luther University
- Guido Mastrobuoni
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology
- Orsalia-Georgia Hazapis
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology
- Simone Del Giudice
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology
- David Schwefel
- Charite-Universitätsmedizin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics
- Nadine Bley
- Institute of Molecular Medicine, Medical Faculty, Martin Luther University
- Franka Voigt
- Friedrich Miescher Institute for Biomedical Research
- Jeffrey A. Chao
- Friedrich Miescher Institute for Biomedical Research
- Stefan Kempa
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology
- Stefan Hüttelmaier
- Institute of Molecular Medicine, Medical Faculty, Martin Luther University
- Matthias Selbach
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology
- Markus Landthaler
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology
- DOI
- https://doi.org/10.1038/s41467-022-30322-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
RNA binding protein HDLBP (or Vigilin) localizes in the endoplasmic reticulum (ER) membrane. Here the authors show that HDLBP contributes to translation of ER-targeted mRNAs.
