TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

Juan J. Montero; Isabel López-Silanes; Diego Megías; Mario F. Fraga; Álvaro Castells-García; Maria A. Blasco

doi:10.1038/s41467-018-03916-3

Nature Communications (Apr 2018)

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

Juan J. Montero,
Isabel López-Silanes,
Diego Megías,
Mario F. Fraga,
Álvaro Castells-García,
Maria A. Blasco

Affiliations

Juan J. Montero: Telomeres and Telomerase Group, Molecular Oncology Program
Isabel López-Silanes: Telomeres and Telomerase Group, Molecular Oncology Program
Diego Megías: Confocal Microscopy Unit, Spanish National Cancer Centre (CNIO)
Mario F. Fraga: Cancer Epigenetics Laboratory, Nanomaterials and Nanotechnology Research Center (CINN-CSIC)-Universidad de Oviedo, Institute of Oncology of Asturias (IUOPA) and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
Álvaro Castells-García: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Maria A. Blasco: Telomeres and Telomerase Group, Molecular Oncology Program

DOI: https://doi.org/10.1038/s41467-018-03916-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Long non-coding RNA TERRAs are essential for telomere protection and telomere length maintenance. Here the authors report a role for TERRAs in telomeric heterochromatin formation by recruiting Polycomb Repressive Complex 2 to telomeres.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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