Establishment of induced pluripotent stem cell line (GSPHi001-A) from a 6-year old female with nephrotic syndrome

Xia Gao; Xin Gao; Haiyan Zhao; Weijing Cui; Mei Tan; Hui Deng

Stem Cell Research (Dec 2019)

Establishment of induced pluripotent stem cell line (GSPHi001-A) from a 6-year old female with nephrotic syndrome

Xia Gao,
Xin Gao,
Haiyan Zhao,
Weijing Cui,
Mei Tan,
Hui Deng

Affiliations

Xia Gao: Nephrology department, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China; Pediatric department, Gansu provincial Hospital, Lanzhou 730000, China; Corresponding author.
Xin Gao: Intensive care unit, Gansu provincial Hospital, Lanzhou 730000, China
Haiyan Zhao: Pediatric department, Gansu provincial Hospital, Lanzhou 730000, China
Weijing Cui: Pediatric department, Gansu provincial Hospital, Lanzhou 730000, China
Mei Tan: Nephrology department, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China
Hui Deng: Nephrology department, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China

Journal volume & issue: Vol. 41

Abstract

Read online

Peripheral blood mononuclear cells (PBMCs) were collected from a 6-year-old female child who was clinically diagnosed as primary nephrotic syndrome (NS) with hormone resistance. An iPSC line was successfully established by the Sendai-virus (SeV) delivery system. The iPS-19 (GSPHi001-A) expressed pluripotent markers, exhibited a normal karyotype and differentiated towards three germ layers. The iPSC line might offer a potentially useful tool for investigating mechanisms of primary NS, drug testing and gene therapy studies.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

About the journal