PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions

Xiaocen Jin; Hikari Tanaka; Meihua Jin; Kyota Fujita; Hidenori Homma; Maiko Inotsume; Huang Yong; Kenichi Umeda; Noriyuki Kodera; Toshio Ando; Hitoshi Okazawa

doi:10.1038/s41467-022-35602-w

Nature Communications (Jan 2023)

PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions

Xiaocen Jin,
Hikari Tanaka,
Meihua Jin,
Kyota Fujita,
Hidenori Homma,
Maiko Inotsume,
Huang Yong,
Kenichi Umeda,
Noriyuki Kodera,
Toshio Ando,
Hitoshi Okazawa

Affiliations

Xiaocen Jin: Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University
Hikari Tanaka: Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University
Meihua Jin: Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University
Kyota Fujita: Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University
Hidenori Homma: Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University
Maiko Inotsume: Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University
Huang Yong: Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University
Kenichi Umeda: Nano Life Science Institute, Kanazawa University, Kakuma-machi
Noriyuki Kodera: Nano Life Science Institute, Kanazawa University, Kakuma-machi
Toshio Ando: Nano Life Science Institute, Kanazawa University, Kakuma-machi
Hitoshi Okazawa: Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University

DOI: https://doi.org/10.1038/s41467-022-35602-w
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 20

Abstract

Read online

The nucleolus is a liquid-liquid phase separation droplet that dynamically changes under stress. Here, the authors report PQBP5/NOL10 is a critical component of the nucleolus, maintaining its structure and position in the nucleus during osmotic stress.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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