Frontiers in Endocrinology (May 2025)
Serum concentrations of medroxyprogesterone acetate were undetectable on OPU+5 days and had no effect on the serum progesterone level in patients undergoing the progestin-primed ovarian stimulation protocol
- Xin Chen,
- Xin Chen,
- Xin Chen,
- Xin Chen,
- Xin Chen,
- Xu Yan,
- Xu Yan,
- Xu Yan,
- Xu Yan,
- Xu Yan,
- Hongyi Xu,
- Hongyi Xu,
- Hongyi Xu,
- Hongyi Xu,
- Hongyi Xu,
- Yueyue Hu,
- Yueyue Hu,
- Yueyue Hu,
- Yueyue Hu,
- Yueyue Hu,
- Shengfang Jiang,
- Shengfang Jiang,
- Shengfang Jiang,
- Shengfang Jiang,
- Shengfang Jiang,
- Xiaoning Wang,
- Xiaoning Wang,
- Xiaoning Wang,
- Xiaoning Wang,
- Xiaoning Wang,
- Haiying Peng,
- Haiying Peng,
- Haiying Peng,
- Haiying Peng,
- Haiying Peng,
- Bo Feng,
- Bo Feng,
- Bo Feng,
- Changjun Zhang,
- Changjun Zhang,
- Changjun Zhang,
- Changjun Zhang,
- Changjun Zhang,
- Honglu Diao,
- Honglu Diao,
- Honglu Diao,
- Honglu Diao,
- Honglu Diao,
- Ying Zhang,
- Ying Zhang,
- Ying Zhang,
- Ying Zhang,
- Ying Zhang
Affiliations
- Xin Chen
- Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Xin Chen
- Hubei Clinical Research Center for Reproductive Medicine, Shiyan, China
- Xin Chen
- Biomedical Engineering College, Hubei University of Medicine, Shiyan, China
- Xin Chen
- Biomedical Research Institute, Hubei University of Medicine, Shiyan, China
- Xin Chen
- Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China
- Xu Yan
- Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Xu Yan
- Hubei Clinical Research Center for Reproductive Medicine, Shiyan, China
- Xu Yan
- Biomedical Engineering College, Hubei University of Medicine, Shiyan, China
- Xu Yan
- Biomedical Research Institute, Hubei University of Medicine, Shiyan, China
- Xu Yan
- Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China
- Hongyi Xu
- Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Hongyi Xu
- Hubei Clinical Research Center for Reproductive Medicine, Shiyan, China
- Hongyi Xu
- Biomedical Engineering College, Hubei University of Medicine, Shiyan, China
- Hongyi Xu
- Biomedical Research Institute, Hubei University of Medicine, Shiyan, China
- Hongyi Xu
- Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China
- Yueyue Hu
- Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Yueyue Hu
- Hubei Clinical Research Center for Reproductive Medicine, Shiyan, China
- Yueyue Hu
- Biomedical Engineering College, Hubei University of Medicine, Shiyan, China
- Yueyue Hu
- Biomedical Research Institute, Hubei University of Medicine, Shiyan, China
- Yueyue Hu
- Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China
- Shengfang Jiang
- Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Shengfang Jiang
- Hubei Clinical Research Center for Reproductive Medicine, Shiyan, China
- Shengfang Jiang
- Biomedical Engineering College, Hubei University of Medicine, Shiyan, China
- Shengfang Jiang
- Biomedical Research Institute, Hubei University of Medicine, Shiyan, China
- Shengfang Jiang
- Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China
- Xiaoning Wang
- Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Xiaoning Wang
- Hubei Clinical Research Center for Reproductive Medicine, Shiyan, China
- Xiaoning Wang
- Biomedical Engineering College, Hubei University of Medicine, Shiyan, China
- Xiaoning Wang
- Biomedical Research Institute, Hubei University of Medicine, Shiyan, China
- Xiaoning Wang
- Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China
- Haiying Peng
- Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Haiying Peng
- Hubei Clinical Research Center for Reproductive Medicine, Shiyan, China
- Haiying Peng
- Biomedical Engineering College, Hubei University of Medicine, Shiyan, China
- Haiying Peng
- Biomedical Research Institute, Hubei University of Medicine, Shiyan, China
- Haiying Peng
- Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China
- Bo Feng
- Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Bo Feng
- Hubei Clinical Research Center for Reproductive Medicine, Shiyan, China
- Bo Feng
- Biomedical Engineering College, Hubei University of Medicine, Shiyan, China
- Changjun Zhang
- Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Changjun Zhang
- Hubei Clinical Research Center for Reproductive Medicine, Shiyan, China
- Changjun Zhang
- Biomedical Engineering College, Hubei University of Medicine, Shiyan, China
- Changjun Zhang
- Biomedical Research Institute, Hubei University of Medicine, Shiyan, China
- Changjun Zhang
- Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China
- Honglu Diao
- Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Honglu Diao
- Hubei Clinical Research Center for Reproductive Medicine, Shiyan, China
- Honglu Diao
- Biomedical Engineering College, Hubei University of Medicine, Shiyan, China
- Honglu Diao
- Biomedical Research Institute, Hubei University of Medicine, Shiyan, China
- Honglu Diao
- Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China
- Ying Zhang
- Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, China
- Ying Zhang
- Hubei Clinical Research Center for Reproductive Medicine, Shiyan, China
- Ying Zhang
- Biomedical Engineering College, Hubei University of Medicine, Shiyan, China
- Ying Zhang
- Biomedical Research Institute, Hubei University of Medicine, Shiyan, China
- Ying Zhang
- Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, China
- DOI
- https://doi.org/10.3389/fendo.2025.1490839
- Journal volume & issue
-
Vol. 16
Abstract
ObjectiveTo evaluate the dynamics of serum medroxyprogesterone acetate (MPA) concentrations and their influence on serum progesterone (P) levels and pregnancy outcomes in the progestin-primed ovarian stimulation (PPOS) protocol. A total of 116 patients who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment using the PPOS protocol were included. Serum MPA levels were measured on the third, fifth, and seventh days of MPA use; on the day of human chorionic gonadotropin (hCG) trigger; and two and five days after oocyte pick-up (OPU).ResultsThe serum MPA concentration was 2.26 ± 2.11 nmol/L on the hCG trigger day, 0.37 ± 0.40 nmol/L two days after OPU, and zero five days after OPU. There were no statistically significant differences in P levels on the hCG trigger day, total dosage of Gn, duration of Gn, number of oocytes retrieved, number of mature oocytes, fertilization rate, blastocyst progression rate, CPR, ectopic pregnancy rate, early pregnancy loss rate, or live birth rate (LBR) between the two cohorts (P > 0.05).Conclusion(s)Serum concentrations of MPA had no effect on serum P levels or pregnancy outcomes in patients undergoing the PPOS protocol.
Keywords
- progestin-primed ovarian stimulation
- medroxyprogesterone acetate
- progesterone level
- MPA concentrations
- pregnancy outcome
