Supramolecular drug inclusion complex of Capecitabine with cucurbit[7]uril and inverted cucurbit[7]uril

Hai-Yan Wang; Yang Zhou; Ji-Hong Lu; Qing-Yun Liu; Gui-Ying Chen; Zhu Tao; Xin Xiao

Arabian Journal of Chemistry (Jan 2020)

Supramolecular drug inclusion complex of Capecitabine with cucurbit[7]uril and inverted cucurbit[7]uril

Hai-Yan Wang,
Yang Zhou,
Ji-Hong Lu,
Qing-Yun Liu,
Gui-Ying Chen,
Zhu Tao,
Xin Xiao

Affiliations

Hai-Yan Wang: Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Yang Zhou: College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Key Laboratory of Fine Chemicals, Shandong Normal University, Jinan 250014, China
Ji-Hong Lu: Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Qing-Yun Liu: Shandong University of Science and Technology, Qingdao 266590, China
Gui-Ying Chen: Yushan Central Crimary School of Taohong Township in Longhui County, Shaoyang 422200, China
Zhu Tao: Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Xin Xiao: Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China; Corresponding author.

Journal volume & issue: Vol. 13, no. 1
pp. 2271 – 2275

Abstract

Read online

The interaction of capecitabine (CAP) with cucurbit[7]uril (Q[7]) and inverted cucurbit[7]uril (iQ[7]) was investigated using nuclear magnetic resonance, fluorescence spectroscopy, MALDI-TOF mass spectrometry and isothermal titration calorimetry. The obtained results revealed that the alkyl chain of CAP is located inside the cavities of Q[7] or iQ[7], whereas the other section of CAP remains outside the portal. Our results suggest that both Q[7] and iQ[7] could be promising candidates for excipients used in medicinal and pharmaceutical research fields.

Published in Arabian Journal of Chemistry

ISSN: 1878-5352 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/arabian-journal-of-chemistry/

About the journal