Prevalence and Correlation of Margin Status and Residual Disease in Subsequent Hysterectomized Specimens Following Loop Electrosurgical Excision Procedure (LEEP)

Abstract

Objectives: To evaluate the prevalence of residual disease in the subsequent hysterectomy specimens after loop electrosurgical excision procedure (LEEP) and its correlation with adequacy of margins in the previous specimens.Materials and methods: Medical records and pathologic reports of patients who were diagnosed of squamous intraepithelial lesion (low grade squamous intraepithelial lesion: LSIL, high grade squamous intraepithelial lesion: HSIL and carcinoma in situ: CIS) or microinvasive squamous cervical carcinoma (MIC) in the LEEP specimens from November 2010 to July 2012 at Sawanpracharak Hospital, Nakhonsawan Province were reviewed. All patients had subsequent hysterectomy within 6 months after the diagnosis. Results:The prevalence of residual disease was 66.2%. Among 227 women with positive LEEP margins, 171 (75.3%) had residual disease in subsequent hysterectomy specimens, while 17 (29.8%) of 57 women with negative LEEP margins had residual lesions. There was a significant correlation of margin status and residual disease in the subsequent hysterectomy specimens following LEEP (p<0.0005). Conclusion: The prevalence of residual disease in the subsequent hysterectomy specimens after LEEP was high. Positive margin in LEEP specimen was the significant predictor of residual disease in hysterectomy specimen.

Keywords

• LEEP
• margin status
• residual disease