Communications Biology (Oct 2022)

Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium

  • Léa Conchou,
  • Bastien Doumèche,
  • Frédéric Galisson,
  • Sébastien Violot,
  • Chloé Dugelay,
  • Eric Diesis,
  • Adeline Page,
  • Anne-Lise Bienvenu,
  • Stéphane Picot,
  • Nushin Aghajari,
  • Lionel Ballut

DOI
https://doi.org/10.1038/s42003-022-04091-4
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 13

Abstract

Read online

Structural and functional analyses of yeast metacaspase reveal unique Ca2+ and Mg2+ binding sites and provide insights into Ca2+-dependent maturation of metacaspases along with the inhibitory effects of Mg2+ and Zn2+.