Frontiers in Neurology (Jun 2020)
Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke
- Yimo Zhou,
- Yimo Zhou,
- Yimo Zhou,
- Yimo Zhou,
- Yuesong Pan,
- Yuesong Pan,
- Yuesong Pan,
- Yuesong Pan,
- Hongyi Yan,
- Hongyi Yan,
- Hongyi Yan,
- Hongyi Yan,
- Yilong Wang,
- Yilong Wang,
- Yilong Wang,
- Yilong Wang,
- Zixiao Li,
- Zixiao Li,
- Zixiao Li,
- Zixiao Li,
- Xingquan Zhao,
- Xingquan Zhao,
- Xingquan Zhao,
- Xingquan Zhao,
- Hao Li,
- Hao Li,
- Hao Li,
- Hao Li,
- Xia Meng,
- Xia Meng,
- Xia Meng,
- Xia Meng,
- Chunxue Wang,
- Chunxue Wang,
- Chunxue Wang,
- Chunxue Wang,
- Liping Liu,
- Liping Liu,
- Liping Liu,
- Liping Liu,
- Yongjun Wang,
- Yongjun Wang,
- Yongjun Wang,
- Yongjun Wang
Affiliations
- Yimo Zhou
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yimo Zhou
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yimo Zhou
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yimo Zhou
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yuesong Pan
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yuesong Pan
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yuesong Pan
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yuesong Pan
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Hongyi Yan
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Hongyi Yan
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Hongyi Yan
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Hongyi Yan
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yilong Wang
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yilong Wang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yilong Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yilong Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Zixiao Li
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Zixiao Li
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Zixiao Li
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Zixiao Li
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Xingquan Zhao
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xingquan Zhao
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Xingquan Zhao
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Xingquan Zhao
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Hao Li
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Hao Li
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Hao Li
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Hao Li
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Xia Meng
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xia Meng
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Xia Meng
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Xia Meng
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Chunxue Wang
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Chunxue Wang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Chunxue Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Chunxue Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Liping Liu
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Liping Liu
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Liping Liu
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Liping Liu
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yongjun Wang
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yongjun Wang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yongjun Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yongjun Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- DOI
- https://doi.org/10.3389/fneur.2020.00456
- Journal volume & issue
-
Vol. 11
Abstract
Background: The triglyceride glucose index (TyG index) has been proposed as a simple and credible surrogate marker of insulin resistance. However, it is unclear whether TyG index correlates with adverse clinical outcomes in patients with ischemic stroke. Accordingly, this study aimed to explore the relationship between baseline TyG index and clinical outcomes of ischemic stroke individuals.Methods: We included eligible subjects with ischemic stroke from the China National Stroke Registry II for the current analysis. TyG index was calculated and divided into quartiles to explore the relationship with the outcomes of ischemic stroke. Outcomes included stroke recurrence, all-cause mortality, poor functional outcome at 12 months, and neurologic worsening at discharge. Multivariable Cox regression and logistic regression models were performed to explore the correlation of baseline TyG index with the outcomes.Results: Among the 16,310 patients enrolled in the study, the average age was 64.83 ± 11.9 years, and 63.48% were men. The median TyG index was 8.73 (interquartile range, 8.33–9.21). After adjustment for multiple potential covariates, the fourth quartile of TyG index was associated with an increased risk of stroke recurrence (adjusted HR, 1.32; 95% CI, 1.11–1.57; P = 0.002), all-cause mortality (adjusted HR, 1.25; 95%CI, 1.06–1.47; P = 0.01) at 12-month follow-up, and neurological worsening (adjusted OR, 1.26; 95% CI, 1.02–1.55; P = 0.03) at discharge, but not poor functional outcome compared with the first quartile.Conclusion: TyG index representing insulin resistance was associated with an increased risk of stroke recurrence, all-cause mortality, and neurologic worsening in patients with ischemic stroke.
Keywords