Frontiers in Neurology (Jun 2020)

Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke

  • Yimo Zhou,
  • Yimo Zhou,
  • Yimo Zhou,
  • Yimo Zhou,
  • Yuesong Pan,
  • Yuesong Pan,
  • Yuesong Pan,
  • Yuesong Pan,
  • Hongyi Yan,
  • Hongyi Yan,
  • Hongyi Yan,
  • Hongyi Yan,
  • Yilong Wang,
  • Yilong Wang,
  • Yilong Wang,
  • Yilong Wang,
  • Zixiao Li,
  • Zixiao Li,
  • Zixiao Li,
  • Zixiao Li,
  • Xingquan Zhao,
  • Xingquan Zhao,
  • Xingquan Zhao,
  • Xingquan Zhao,
  • Hao Li,
  • Hao Li,
  • Hao Li,
  • Hao Li,
  • Xia Meng,
  • Xia Meng,
  • Xia Meng,
  • Xia Meng,
  • Chunxue Wang,
  • Chunxue Wang,
  • Chunxue Wang,
  • Chunxue Wang,
  • Liping Liu,
  • Liping Liu,
  • Liping Liu,
  • Liping Liu,
  • Yongjun Wang,
  • Yongjun Wang,
  • Yongjun Wang,
  • Yongjun Wang

DOI
https://doi.org/10.3389/fneur.2020.00456
Journal volume & issue
Vol. 11

Abstract

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Background: The triglyceride glucose index (TyG index) has been proposed as a simple and credible surrogate marker of insulin resistance. However, it is unclear whether TyG index correlates with adverse clinical outcomes in patients with ischemic stroke. Accordingly, this study aimed to explore the relationship between baseline TyG index and clinical outcomes of ischemic stroke individuals.Methods: We included eligible subjects with ischemic stroke from the China National Stroke Registry II for the current analysis. TyG index was calculated and divided into quartiles to explore the relationship with the outcomes of ischemic stroke. Outcomes included stroke recurrence, all-cause mortality, poor functional outcome at 12 months, and neurologic worsening at discharge. Multivariable Cox regression and logistic regression models were performed to explore the correlation of baseline TyG index with the outcomes.Results: Among the 16,310 patients enrolled in the study, the average age was 64.83 ± 11.9 years, and 63.48% were men. The median TyG index was 8.73 (interquartile range, 8.33–9.21). After adjustment for multiple potential covariates, the fourth quartile of TyG index was associated with an increased risk of stroke recurrence (adjusted HR, 1.32; 95% CI, 1.11–1.57; P = 0.002), all-cause mortality (adjusted HR, 1.25; 95%CI, 1.06–1.47; P = 0.01) at 12-month follow-up, and neurological worsening (adjusted OR, 1.26; 95% CI, 1.02–1.55; P = 0.03) at discharge, but not poor functional outcome compared with the first quartile.Conclusion: TyG index representing insulin resistance was associated with an increased risk of stroke recurrence, all-cause mortality, and neurologic worsening in patients with ischemic stroke.

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