Molecular Mechanisms of West Nile Virus Pathogenesis in Brain Cells

Abstract

We analyzed the response of human glioma cells to West Nile virus infection by investigating host transcriptional changes. Changes in expression of 23 genes showed similarities to those in other neurodegenerative diseases. These changes may be useful as potential biomarkers and elucidate novel mechanisms behind the neuropathology of infection with this virus.

Keywords

• Flaviviruses
• gene expression
• microarray
• real-time PCR
• human glioblastoma cells
• neuronal damage