Nature Communications (Nov 2022)
Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations
- Harry A. Thorpe,
- Elise Tourrette,
- Koji Yahara,
- Filipa F. Vale,
- Siqi Liu,
- Mónica Oleastro,
- Teresa Alarcon,
- Tsachi-Tsadok Perets,
- Saeid Latifi-Navid,
- Yoshio Yamaoka,
- Beatriz Martinez-Gonzalez,
- Ioannis Karayiannis,
- Timokratis Karamitros,
- Dionyssios N. Sgouras,
- Wael Elamin,
- Ben Pascoe,
- Samuel K. Sheppard,
- Jukka Ronkainen,
- Pertti Aro,
- Lars Engstrand,
- Lars Agreus,
- Sebastian Suerbaum,
- Kaisa Thorell,
- Daniel Falush
Affiliations
- Harry A. Thorpe
- Department of Biostatistics, University of Oslo
- Elise Tourrette
- CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
- Koji Yahara
- Antimicrobial Resistance Research Center, National Institute of Infectious Diseases
- Filipa F. Vale
- Pathogen Genome Bioinformatics and Computational Biology, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa
- Siqi Liu
- CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
- Mónica Oleastro
- National Reference Laboratory for Gastrointestinal Infections, Department of Infectious Diseases, National Institute of Health Dr Ricardo Jorge
- Teresa Alarcon
- Department of Microbiology, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria Princesa
- Tsachi-Tsadok Perets
- Gastroenterology Laboratory, Rabin Medical Center
- Saeid Latifi-Navid
- Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili
- Yoshio Yamaoka
- Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine
- Beatriz Martinez-Gonzalez
- Laboratory of Medical Microbiology, Hellenic Pasteur Institute
- Ioannis Karayiannis
- Laboratory of Medical Microbiology, Hellenic Pasteur Institute
- Timokratis Karamitros
- Laboratory of Medical Microbiology, Hellenic Pasteur Institute
- Dionyssios N. Sgouras
- Laboratory of Medical Microbiology, Hellenic Pasteur Institute
- Wael Elamin
- G42 Healthcare
- Ben Pascoe
- Department of Biology, University of Oxford
- Samuel K. Sheppard
- Ineos Oxford Institute, Department of Biology, University of Oxford
- Jukka Ronkainen
- Center for Life Course Health Research, University of Oulu
- Pertti Aro
- Arokero Oy
- Lars Engstrand
- Center for Translational Microbiome Research, Department for Microbiology, Tumor, and Cell Biology, Karolinska Institutet
- Lars Agreus
- Division of Family Medicine, Karolinska Institutet
- Sebastian Suerbaum
- Department of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer Institute, Faculty of Medicine, LMU Munich
- Kaisa Thorell
- Institute of Biomedicine, Department of Infectious Diseases, University of Gothenburg
- Daniel Falush
- CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-022-34475-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Helicobacter pylori is a major human pathogen whose population structure is similar to that of its host. Here, the authors show that H. pylori has repeatedly spread out of Africa recently, replacing deleterious variants that accumulated during the original out of Africa migrations more than 50,000 years ago.
