Cotransporter-mediated water transport underlying cerebrospinal fluid formation

Annette B. Steffensen; Eva K. Oernbo; Anca Stoica; Niklas J. Gerkau; Dagne Barbuskaite; Katerina Tritsaris; Christine R. Rose; Nanna MacAulay

doi:10.1038/s41467-018-04677-9

Nature Communications (Jun 2018)

Cotransporter-mediated water transport underlying cerebrospinal fluid formation

Annette B. Steffensen,
Eva K. Oernbo,
Anca Stoica,
Niklas J. Gerkau,
Dagne Barbuskaite,
Katerina Tritsaris,
Christine R. Rose,
Nanna MacAulay

Affiliations

Annette B. Steffensen: Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen
Eva K. Oernbo: Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen
Anca Stoica: Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen
Niklas J. Gerkau: Institute of Neurobiology, Heinrich Heine University Duesseldorf
Dagne Barbuskaite: Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
Katerina Tritsaris: Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
Christine R. Rose: Institute of Neurobiology, Heinrich Heine University Duesseldorf
Nanna MacAulay: Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen

DOI: https://doi.org/10.1038/s41467-018-04677-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Osmotic forces do not suffice to explain the rate of cerebrospinal fluid (CSF) production. Here, the authors show that the Na+/K+/2Cl− cotransporter in the choroid plexus contributes substantially to CSF production via its inherent ability to cotransport water.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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