Structural basis for clearing of ribosome collisions by the RQT complex

Katharina Best; Ken Ikeuchi; Lukas Kater; Daniel Best; Joanna Musial; Yoshitaka Matsuo; Otto Berninghausen; Thomas Becker; Toshifumi Inada; Roland Beckmann

doi:10.1038/s41467-023-36230-8

Nature Communications (Feb 2023)

Structural basis for clearing of ribosome collisions by the RQT complex

Katharina Best,
Ken Ikeuchi,
Lukas Kater,
Daniel Best,
Joanna Musial,
Yoshitaka Matsuo,
Otto Berninghausen,
Thomas Becker,
Toshifumi Inada,
Roland Beckmann

Affiliations

Katharina Best: Department of Biochemistry, Gene Center, Feodor-Lynen-Str. 25, University of Munich
Ken Ikeuchi: Department of Biochemistry, Gene Center, Feodor-Lynen-Str. 25, University of Munich
Lukas Kater: Department of Biochemistry, Gene Center, Feodor-Lynen-Str. 25, University of Munich
Daniel Best: Department of Biochemistry, Gene Center, Feodor-Lynen-Str. 25, University of Munich
Joanna Musial: Department of Biochemistry, Gene Center, Feodor-Lynen-Str. 25, University of Munich
Yoshitaka Matsuo: Division of RNA and gene regulation, Institute of Medical Science, The University of Tokyo
Otto Berninghausen: Department of Biochemistry, Gene Center, Feodor-Lynen-Str. 25, University of Munich
Thomas Becker: Department of Biochemistry, Gene Center, Feodor-Lynen-Str. 25, University of Munich
Toshifumi Inada: Division of RNA and gene regulation, Institute of Medical Science, The University of Tokyo
Roland Beckmann: Department of Biochemistry, Gene Center, Feodor-Lynen-Str. 25, University of Munich

DOI: https://doi.org/10.1038/s41467-023-36230-8
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 12

Abstract

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Ribosome collisions serve as proxy for aberrant translation to initiate rescue and quality control pathways. Here, authors elucidate the molecular mechanism of collided ribosome clearance by the ribosome quality control trigger complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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