Simultaneous triple-parametric optical mapping of transmembrane potential, intracellular calcium and NADH for cardiac physiology assessment

Sharon A. George; Zexu Lin; Igor R. Efimov

doi:10.1038/s42003-022-03279-y

Communications Biology (Apr 2022)

Simultaneous triple-parametric optical mapping of transmembrane potential, intracellular calcium and NADH for cardiac physiology assessment

Sharon A. George,
Zexu Lin,
Igor R. Efimov

Affiliations

Sharon A. George: Department of Biomedical Engineering, The George Washington University
Zexu Lin: Department of Biomedical Engineering, The George Washington University
Igor R. Efimov: Department of Biomedical Engineering, The George Washington University

DOI: https://doi.org/10.1038/s42003-022-03279-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

Read online

Simultaneous triple-parametric optical mapping of transmembrane potential, intracellular calcium, and metabolic markers for cardiac physiology shows that metabolic changes precede the effects of ischemia on cardiac electrophysiology.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal