BMC Research Notes (Jul 2011)

Analysis of MMP2 promoter polymorphisms in childhood obesity

  • Thompson John MD,
  • Han Dug,
  • Morgan Angharad R,
  • Mitchell Edwin A,
  • Ferguson Lynnette R

DOI
https://doi.org/10.1186/1756-0500-4-253
Journal volume & issue
Vol. 4, no. 1
p. 253

Abstract

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Abstract Background Several lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of childhood obesity in a New Zealand population. Findings 546 samples from the Auckland Birthweight Collaborative (ABC) study were genotyped for the three MMP-2 promoter SNPs -1306 C/T (rs243865), -1575G/A (rs243866) and -790 T/G (rs243864) using the Sequenom genotyping platform. The results demonstrated that an MMP-2 promoter haplotype is associated with PBF in New Zealand 7 year old children. Conclusion We have previously determined that environmental factors are associated with differences in PBF in this study group, and now we have demonstrated a possible genetic contribution.

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