STUDY OF CHARACTERISTIC PARAMETERS OF THE MICROEMULSION COMPOSITION FOR TRANSDERMAL INSULIN DELIVERY

Abstract

The article is about the study of the characteristic properties of a microemulsion composition for insulin transdermal therapeutic system (TTS). The type of microemulsion "water in oil" was determined and its stability was investigated. Instrumental methods have been used to evaluate parameters such as refractive index, viscosity and particle size. The conditions for the release of insulin from the microemulsion have been found, which make it possible to ensure the release of the hormone into a volume more than 95% of the claimed amount. In vitro study hormone diffusion from TDS containing a microemulsion with insulin through the native rabbit skin was ~1 U/h. It corresponds to hormone rate secretion by the pancreas of a healthy person.

Keywords

• microemulsion
• particle size
• release
• liquid chromatography
• insulin