Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine

Petter  I. Andersen; Klara Krpina; Aleksandr Ianevski; Nastassia Shtaida; Eunji Jo; Jaewon Yang; Sandra Koit; Tanel Tenson; Veijo Hukkanen; Marit  W. Anthonsen; Magnar Bjoras; Magnus Evander; Marc  P. Windisch; Eva Zusinaite; Denis  E. Kainov

doi:10.3390/v11100964

Viruses (Oct 2019)

Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine

Petter I. Andersen,
Klara Krpina,
Aleksandr Ianevski,
Nastassia Shtaida,
Eunji Jo,
Jaewon Yang,
Sandra Koit,
Tanel Tenson,
Veijo Hukkanen,
Marit W. Anthonsen,
Magnar Bjoras,
Magnus Evander,
Marc P. Windisch,
Eva Zusinaite,
Denis E. Kainov

Affiliations

Petter I. Andersen: Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway
Klara Krpina: Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway
Aleksandr Ianevski: Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway
Nastassia Shtaida: Institute of Technology, University of Tartu, Tartu 50090, Estonia
Eunji Jo: Applied Molecular Virology Laboratory, Institut Pasteur Korea, 696 Sampyung-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Korea
Jaewon Yang: Applied Molecular Virology Laboratory, Institut Pasteur Korea, 696 Sampyung-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Korea
Sandra Koit: Institute of Technology, University of Tartu, Tartu 50090, Estonia
Tanel Tenson: Institute of Technology, University of Tartu, Tartu 50090, Estonia
Veijo Hukkanen: Institute of Biomedicine, University of Turku, 20520 Turku, Finland
Marit W. Anthonsen: Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway
Magnar Bjoras: Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway
Magnus Evander: Department of Clinical Microbiology, Virology, Umeå University, 90185 Umeå, Sweden
Marc P. Windisch: Applied Molecular Virology Laboratory, Institut Pasteur Korea, 696 Sampyung-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Korea
Eva Zusinaite: Institute of Technology, University of Tartu, Tartu 50090, Estonia
Denis E. Kainov: Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway

DOI: https://doi.org/10.3390/v11100964
Journal volume & issue: Vol. 11, no. 10
p. 964

Abstract

Read online

Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization, there is an urgent need for better control of viral diseases. Repurposing existing antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we identified novel activities of obatoclax and emetine against herpes simplex virus type 2 (HSV-2), echovirus 1 (EV1), human metapneumovirus (HMPV) and Rift Valley fever virus (RVFV) in cell cultures. Moreover, we demonstrated novel activities of emetine against influenza A virus (FLUAV), niclosamide against HSV-2, brequinar against human immunodeficiency virus 1 (HIV-1), and homoharringtonine against EV1. Our findings may expand the spectrum of indications of these safe-in-man agents and reinforce the arsenal of available antiviral therapeutics pending the results of further in vitro and in vivo tests.

Published in Viruses

ISSN: 1999-4915 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/viruses

About the journal

Abstract

Keywords