Neurobiology of Disease (Mar 2007)

The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-ε4 non-carriers in the Italian Alzheimer’s disease population and does not affect the plasma Aβ(1–42) level

  • Marzia Pesaresi,
  • Sara Batelli,
  • Francesca Prato,
  • Letizia Polito,
  • Carlo Lovati,
  • Elio Scarpini,
  • Pierluigi Quadri,
  • Claudio Mariani,
  • Diego Albani,
  • Gianluigi Forloni

DOI
https://doi.org/10.1016/j.nbd.2006.10.017
Journal volume & issue
Vol. 25, no. 3
pp. 609 – 613

Abstract

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Sporadic Alzheimer’s disease (AD) is the most frequent form of dementia in the elderly. A non-conservative polymorphism in the urokinase-type plasminogen activator gene (PLAU_1=RS2227564) has been analyzed, but data are conflicting on whether it is a risk factor for AD. To clarify whether this genetic variant modifies AD risk in the Italian population, we ran a case–control association study on 192 AD and 126 age-matched controls. We did not find any association between PLAU_1 genotype and AD in the whole AD population, but when we stratified our sample by APOE-ε4 status, we found a significant association between PLAU_1 genotype (C/T+T/T) and APOE-ε4 negative AD subjects (p=0.02, χ2-test). The PLAU_1 genotype did not appear to affect the plasma Aβ42 concentration. Our data support a role for PLAU_1 as an independent genetic risk factor for AD in the Italian population for those subjects who do not have the APOE-ε4 allele.

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