SYNTHESIS, CHARACTERISATION AND BIOLOGICAL ACTIVITY OF ORGANOTIN DERIVATIVES OF DICLOFENAC SODIUM

Abstract

Two organotin complexes, trimethyltin and diphenyltin with diclofenac sodium as ligand, were prepared. Structure elucidation of the complexes prepared was carried out by infrared, multi nuclear magnetic resonance and mass spectroscopy. The spectral data suggest that trimethyltin diclofenate is four coordinate tetrahedral monomer while diphenyltin bis (diclofenate) retained its hexa coordinated octahedral geometry in solution. The biological activity of these two complexes proved to be powerful biocides.

Keywords

• Organotin derivatives
• Diclofenac sodium
• Spectroscopic techniques
• Antifungal activity