Synthesis of Quinoxalin-2(1H)-ones and Hexahydroquinoxalin-2(1H)-ones via Oxidative Amidation–Heterocycloannulation

Akula Raghunadh; Krishnaji Tadiparthi; Suresh Babu Meruva; V. Narayana Murthy; L. Vaikunta Rao; U. K. Syam Kumar

doi:10.1055/s-0040-1707203

SynOpen (Jul 2020)

Synthesis of Quinoxalin-2(1H)-ones and Hexahydroquinoxalin-2(1H)-ones via Oxidative Amidation–Heterocycloannulation

Akula Raghunadh,
Krishnaji Tadiparthi,
Suresh Babu Meruva,
V. Narayana Murthy,
L. Vaikunta Rao,
U. K. Syam Kumar

Affiliations

Akula Raghunadh: Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Ltd
Krishnaji Tadiparthi: Department of Chemistry, CHRIST (Deemed to be University)
Suresh Babu Meruva: Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Ltd
V. Narayana Murthy: Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Ltd
L. Vaikunta Rao: Department of Chemistry, GIS, GITAM University
U. K. Syam Kumar: Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Ltd

DOI: https://doi.org/10.1055/s-0040-1707203
Journal volume & issue: Vol. 04, no. 03
pp. 55 – 61

Abstract

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Abstract A metal-catalyst-free synthesis of substituted quinoxalin-2-ones from 2,2-dibromo-1-arylethanone by employing an oxidative amidation–heterocycloannulation protocol is reported. The substrate scope of the reaction has been demonstrated and a possible mechanism for this reaction has also been proposed.

Published in SynOpen

ISSN: 2509-9396 (Online)
Publisher: Georg Thieme Verlag KG
Country of publisher: Germany
LCC subjects: Science: Chemistry
Website: https://doi.org/10.1055/s-00032269

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Abstract

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