The Chemical Components of <em>Sesbania grandiflora</em> Root and Their Antituberculosis Activity

Abstract

Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of <em>Sesbania grandiflora</em>. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, ¹H- and ¹³C-NMR, DEPT, COSY, HMQC, HMBC, and MS analysis). All the tested compounds 1–4 exhibited antituberculosis activity against <em>Mycobacterium tuberculosis</em> H37Rv, with MIC values of 50 µg/mL for compounds 1–3, and 100 µg/mL for compound 4, whereas, the methanol extract exhibited antituberculosis activity of 625 µg/mL. This is the first report on the occurrence of isoflavonoids in this plant and their antituberculosis activity.

Keywords

• isovestitol
• medicarpin
• sativan
• betulinic acid
• &lt;em&gt;Sesbania&lt;/em&gt;&lt;em&gt; grandiflora&lt;/em&gt;
• antituberculosis activity
• &lt;em&gt;Mycobacterium tuberculosis&lt;/em&gt;