Frontiers in Chemistry (Aug 2021)

pH-Responsive DNA Motif: From Rational Design to Analytical Applications

  • Lin Lin Zheng,
  • Jin Ze Li,
  • Ying Xu Li,
  • Jian Bang Gao,
  • Jiang Xue Dong,
  • Zhong Feng Gao

DOI
https://doi.org/10.3389/fchem.2021.732770
Journal volume & issue
Vol. 9

Abstract

Read online

pH-responsive DNA motifs have attracted substantial attention attributed to their high designability and versatility of DNA chemistry. Such DNA motifs typically exploit DNA secondary structures that exhibit pH response properties because of the presence of specific protonation sites. In this review, we briefly summarized second structure-based pH-responsive DNA motifs, including triplex DNA, i-motif, and A+-C mismatch base pair-based DNA devices. Finally, the challenges and prospects of pH-responsive DNA motifs are also discussed.

Keywords