Endocrine effects on heart function

Abstract

Among the factors associated with thalassemic heart disease, endocrine disturbance is also a contributing factor. We present a retrospective, cross sectional study, which aims to establish the prevalence of cardiac complications in thalassaemia major (TM) patients with endocrine complications and to evaluate the influence of endocrine disease on cardiac complications. Endocrinological and cardiological parameters were considered on 957 TM patients who are enrolled in the Myocardial Iron Overload in Thalassemia (MIOT) network in 68 sites in Italy. Patients with pubertal hypogonadism (163 males and 175 females), hypothyroidism (192), diabetes mellitus (87) and hypoparathyroidism (61), were compared according to cardiac complications: global heart T2*, cardiac dysfunction, heart failure, arrythmias, pulmonary hypertension and myocardial fibrosis. Control groups were made up according to the age range of patients with the corresponding endocrinopathy. The prevalence of cardiac dysfunction, arrhythmias and heart failure was significantly increased in patients with endocrinopathies. Cardiac complications tended to increase according to the number of endocrinologies affecting the patient. 与地中海贫血心脏疾病相关的因素中，内分泌失调也是一个促进因素。 我们进行了回顾和断面研究，旨在患有内分泌并发症的重型地中海贫血患者中建立心脏并发症的患病率，以及评估内分泌疾病对心脏并发症的影响。 曾考虑到意大利地中海贫血心肌铁过载（MIOT）网络的68个站点上注册的957名重型地中海贫血患者的内分泌和心脏病学参数。 根据以下心脏并发症对青春期性腺机能减退的患者（男性163名、女性175名）、甲状腺机能减退患者（192名）、糖尿病患者（87名）和甲状旁腺机能减退患者（61名）进行了比较： 心脏 T2*、心功能障碍、心脏衰竭、心率不齐、肺动脉高血压以及心肌纤维化。 根据相应内分泌病患者的年龄范围建立了对照组。 心功能障碍、心率不齐和心脏衰竭的患病率在内分泌病患者中明显增加。 根据影响患者的内分泌病的数量，心脏并发症倾向于增加。

Keywords

• jeart function, endocrine effects.