Frontiers in Pediatrics (Mar 2022)
Surfactant Therapy for Respiratory Distress Syndrome in High- and Ultra-High-Altitude Settings
- Xudong Duan,
- Xudong Duan,
- Jiujun Li,
- Jiujun Li,
- Long Chen,
- Yuan Shi,
- Xianyang Chen,
- Xianyang Chen,
- Teng Xue,
- Teng Xue,
- Chongde Liu,
- Xiaorong Wang,
- Quanfang Qiu,
- Zhen Yu,
- Bacuozhen Qiang,
- Hong Wu,
- Tianqi Wu,
- Lihong Zhang,
- Zhangsheng Chen,
- Dobje Jigme,
- Aili Xu,
- Zhuoga Mima,
- Zhen Da,
- Min Ren,
- Deji Gesang,
- Zhaxi Pubu,
- Chun Li,
- Yanchao Lv,
- Haoquan Zhou,
- Haoquan Zhou,
- Xue Zhang,
- Xue Zhang,
- Zhuoma Dawa,
- Wujin Gongjue,
- Li Wang,
- Li Wu,
- Xuelian Li
Affiliations
- Xudong Duan
- Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China
- Xudong Duan
- Plateau Medical Research Center of China Medical University, Shenyang, China
- Jiujun Li
- Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China
- Jiujun Li
- Plateau Medical Research Center of China Medical University, Shenyang, China
- Long Chen
- Department of Neonatology, Children's Hospital Affiliated Chongqing Medical University, Chongqing, China
- Yuan Shi
- Department of Neonatology, Children's Hospital Affiliated Chongqing Medical University, Chongqing, China
- Xianyang Chen
- BaoFeng Key Laboratory of Genetics and Metabolism, Beijing, China
- Xianyang Chen
- Zhongguancun Biological and Medical Big Data Center, Beijing, China
- Teng Xue
- Zhongguancun Biological and Medical Big Data Center, Beijing, China
- Teng Xue
- Zhongyuanborui (Hengqin, Zhuhai) Key Laboratory of Genetics and Metabolism, Zhuhai, China
- Chongde Liu
- Department of Neonatology, Qinghai Women and Children's Hospital, Xining, China
- Xiaorong Wang
- Department of Neonatology, Qinghai Women and Children's Hospital, Xining, China
- Quanfang Qiu
- Department of Pediatrics, Lhasa People's Hospital, Lhasa, China
- Zhen Yu
- Department of Pediatrics, Lhasa People's Hospital, Lhasa, China
- Bacuozhen Qiang
- Department of Pediatrics, Lhasa People's Hospital, Lhasa, China
- Hong Wu
- Department of Pediatrics, People's Hospital of Tibet, Tibet, China
- Tianqi Wu
- Department of Pediatrics, People's Hospital of Tibet, Tibet, China
- Lihong Zhang
- 0Department of Pediatrics, Linzhi People's Hospital, Tibet, China
- Zhangsheng Chen
- 1Center of Pediatrics, Zhujiang Hospital, Southern Medical University, Guangzhou, China
- Dobje Jigme
- 2Department of Pediatrics, Naqu People's Hospital, Tibet, China
- Aili Xu
- 3Department of Pediatrics, Shigatse People's Hospital, Tibet, China
- Zhuoga Mima
- 3Department of Pediatrics, Shigatse People's Hospital, Tibet, China
- Zhen Da
- 4Department of Pediatrics, Second People's Hospital of Tibet, Tibet, China
- Min Ren
- 4Department of Pediatrics, Second People's Hospital of Tibet, Tibet, China
- Deji Gesang
- 5Department of Pediatrics, Shannan People's Hospital, Tibet, China
- Zhaxi Pubu
- 5Department of Pediatrics, Shannan People's Hospital, Tibet, China
- Chun Li
- 6Department of Pediatrics, Changdu People's Hospital, Tibet, China
- Yanchao Lv
- 6Department of Pediatrics, Changdu People's Hospital, Tibet, China
- Haoquan Zhou
- 7Department of Pediatrics, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China
- Haoquan Zhou
- 8Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China
- Xue Zhang
- 7Department of Pediatrics, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China
- Xue Zhang
- 8Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China
- Zhuoma Dawa
- 9Department of Pediatrics, People's Hospital of Ali District, Tibet, China
- Wujin Gongjue
- 9Department of Pediatrics, People's Hospital of Ali District, Tibet, China
- Li Wang
- 0Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing, China
- Li Wu
- 0Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing, China
- Xuelian Li
- 0Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing, China
- DOI
- https://doi.org/10.3389/fped.2022.777360
- Journal volume & issue
-
Vol. 10
Abstract
ObjectiveThe objective of this study is to investigate the therapeutic effect of surfactant replacement therapy (SRT) on respiratory distress syndrome (RDS) in premature infants in the Qinghai-Tibet Plateau.Materials and MethodsThis multi-center retrospective cohort study collected and screened reasonable clinical data of 337 premature infants with RDS from 10 hospitals in the Qinghai-Tibet Plateau from 2015 to 2017. We grouped the cases by rationally analyzing their baseline characteristics, using logistic analysis to evaluate each factor's effect on the prognosis of the infants, and comparing the short-term improvement in blood gas and mortality after SRT treatment at different altitudes, in high-altitude (1,500–3,500 m) and ultra-high-altitude (3,500–5,500 m) groups.ResultsIndependent of altitude, the mortality rate of children with RDS in the SRT group was significantly lower than that of children in the non-SRT group (both P < 0.05). The effect of SRT on preterm infants with RDS in the high-altitude group [odds ratio (OR) = 0.44, 95% confidence interval (CI) = 0.22–0.87, P = 0.02] was better than that in the infants in the ultra-high-altitude group (OR = 0.26, 95% CI = 0.13–0.58, P < 0.01), with death rates of 34.34 and 49.71%, respectively. Similarly, after SRT, the improvement of PaO2/FiO2 and pH of children at high altitude was significantly better than those of children at ultra-high altitude (all P < 0.01).ConclusionsSRT plays a prominent role in curing infants with RDS in both high- and ultra-high-altitude regions, although with better effects at high rather than ultra-high altitude. This study provides a basis for further large-scale studies on SRT for RDS treatment at high altitudes.
Keywords
- high-altitude
- ultra-high-altitude
- surfactant replacement therapy
- respiratory distress syndrome
- premature infants
- logistic regression
