Bezmiâlem Science (Apr 2022)
The Role of Platelet Indices, Red Cell Distribution Width and the Ratios of Neutrophil to Lymphocyte, Platelet to Lymphocyte and Lymphocyte to C-reactive Protein as Markers for the Diagnosis of Acute Appendicitis in Children
Abstract
Objective:To determine the role of mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and lymphocyte to C-reactive protein ratio (LCR) for the diagnosis of complicated and uncomplicated acute appendicitis (AA) in children admitted to the hospital with right lower quadrant pain.Methods:The patients presented with right lower quadrant abdominal pain were grouped as acute uncomplicated appendicitis (Group 1), acute complicated appendicitis (Group 2) and right lower quadrant abdominal pain-other than appendicitis (Group 3) groups.Results:In this retrospective study, 1,050 patients were included. There was not a statistically significant difference regarding age and gender between groups (p=0.555 and p=0.641, respectively). No significant difference was observed in the comparison of all groups and between-groups in terms of all laboratory parameters (MPV, p=0.528; PDW, p=0.181; RDW, p=0.479; NLR, p=0.953; PLR, p=0.848; LCR, p=0.535).Conclusion:It was shown that MPV, PDW, RDW, NLR, PLR and LCR aided neither in the differential diagnosis of patients with right lower quadrant pain nor in the discrimination of pediatric acute complicated and uncomplicated appendicitispatients. The explanation for this might be that complete blood cell count could be affected by an inflammatory process other than AA and other characteristics such as anemia, age and sex. Clinical observation and diagnostic imaging modalities should still be the most reliable diagnostic methods in acute appendicitis. The roles of these parameters in the diagnosis of AA can be understood more clearly with multi-center prospective studies with larger sample sizes.
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