Molecules (Dec 2011)

Synthesis of cis- and trans-3-Aminocyclohexanols by Reduction of β-Enaminoketones

  • Irma Linzaga-Elizalde,
  • Blanca Eda Domínguez Mendoza,
  • Mario Ordoñez,
  • Mario Fernández-Zertuche,
  • Iris Montoya Balbás

DOI
https://doi.org/10.3390/molecules17010151
Journal volume & issue
Vol. 17, no. 1
pp. 151 – 162

Abstract

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We describe a protocol developed for the preparation of β-enaminoketones derived from 1,3-cyclohexanediones, and their subsequent reduction by sodium in THF-isopropyl alcohol to afford cis- and trans-3-aminocyclohexanols.

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