Reduced Plasma Levels of Very-Long-Chain Dicarboxylic Acid 28:4 in Italian and Brazilian Colorectal Cancer Patient Cohorts

Paul  L. Wood; Michelle  M. Donohue; John  E. Cebak; Taylor  G. Beckmann; Márcia  Cristina Fernandes Messias; Laura Credidio; Cláudio  Saddy Rodrigues Coy; Patrícia  de Oliveira Carvalho; Sara Crotti; Sara D’Aronco; Emanuele  D.L. Urso; Marco Agostini

doi:10.3390/metabo8040091

Metabolites (Dec 2018)

Reduced Plasma Levels of Very-Long-Chain Dicarboxylic Acid 28:4 in Italian and Brazilian Colorectal Cancer Patient Cohorts

Paul L. Wood,
Michelle M. Donohue,
John E. Cebak,
Taylor G. Beckmann,
Márcia Cristina Fernandes Messias,
Laura Credidio,
Cláudio Saddy Rodrigues Coy,
Patrícia de Oliveira Carvalho,
Sara Crotti,
Sara D’Aronco,
Emanuele D.L. Urso,
Marco Agostini

Affiliations

Paul L. Wood: Metabolomics Unit, College of Veterinary Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy, Harrogate, TN 37752, USA
Michelle M. Donohue: Metabolomics Unit, College of Veterinary Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy, Harrogate, TN 37752, USA
John E. Cebak: Metabolomics Unit, College of Veterinary Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy, Harrogate, TN 37752, USA
Taylor G. Beckmann: Department of Medicine, DeBusk College of Osteopathic Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy., Harrogate, TN 37752, USA
Márcia Cristina Fernandes Messias: Laboratory of Multidisciplinary Research, São Francisco University (USF), Bragança Paulista, São Paulo 12916-900, Brazil
Laura Credidio: Department of Surgery, University of Campinas (UNICAMP), Campinas, São Paulo 12916-900, Brazil
Cláudio Saddy Rodrigues Coy: Department of Surgery, University of Campinas (UNICAMP), Campinas, São Paulo 12916-900, Brazil
Patrícia de Oliveira Carvalho: Laboratory of Multidisciplinary Research, São Francisco University (USF), Bragança Paulista, São Paulo 12916-900, Brazil
Sara Crotti: Nano-Inspired Biomedicine Lab, Istituto di Ricerca Pediatrica-Città della Speranza, 35127 Padua, Italy
Sara D’Aronco: Nano-Inspired Biomedicine Lab, Istituto di Ricerca Pediatrica-Città della Speranza, 35127 Padua, Italy
Emanuele D.L. Urso: First Surgery Clinic, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua 35128, Italy
Marco Agostini: Nano-Inspired Biomedicine Lab, Istituto di Ricerca Pediatrica-Città della Speranza, 35127 Padua, Italy

DOI: https://doi.org/10.3390/metabo8040091
Journal volume & issue: Vol. 8, no. 4
p. 91

Abstract

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Background: There are currently no blood-based biomarkers for early diagnosis of colorectal cancer. Previous research has suggested that very-long-chain dicarboxylic acid (VLCDCA) 28:4 might be such a biomarker. Methods: Using high-resolution mass spectrometry, we analyzed VLCDCA 28:4 in the plasma of colorectal cancer patients in Italian [n = 62] and Brazilian [n = 52] cohorts. Additionally, we investigated individuals diagnosed with familial adenomatous polyposis (FAP; n = 27), one of the most important clinical forms of inherited susceptibility to colorectal cancer. Results: Decrements in plasma levels of VLCDCA 28:4 were monitored in colorectal cancer patients. These decreases were independent of the stage of tumor development and the individual’s age. However, no decrements in VLCDCA 28:4 were monitored in FAP patients. Conclusions: The plasma levels of VLCDCA 28:4 represent a potential biomarker of sporadic colorectal cancer. In addition, it is possible that resupply of this anti-inflammatory lipid may represent a new therapeutic strategy for CRC and inflammatory disorders.

Published in Metabolites

ISSN: 2218-1989 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/metabolites

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