Nature Communications (Feb 2017)
Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress
- Nam Hee Kim,
- Yong Hoon Cha,
- Jueun Lee,
- Seon-Hyeong Lee,
- Ji Hye Yang,
- Jun Seop Yun,
- Eunae Sandra Cho,
- Xianglan Zhang,
- Miso Nam,
- Nami Kim,
- Young-Su Yuk,
- So Young Cha,
- Yoonmi Lee,
- Joo Kyung Ryu,
- Sunghyouk Park,
- Jae-Ho Cheong,
- Sang Won Kang,
- Soo-Youl Kim,
- Geum-Sook Hwang,
- Jong In Yook,
- Hyun Sil Kim
Affiliations
- Nam Hee Kim
- Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry
- Yong Hoon Cha
- Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry
- Jueun Lee
- Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute
- Seon-Hyeong Lee
- Cancer Cell and Molecular Biology Branch, National Cancer Center
- Ji Hye Yang
- Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry
- Jun Seop Yun
- Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry
- Eunae Sandra Cho
- Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry
- Xianglan Zhang
- Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry
- Miso Nam
- Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute
- Nami Kim
- Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute
- Young-Su Yuk
- Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry
- So Young Cha
- Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry
- Yoonmi Lee
- Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry
- Joo Kyung Ryu
- Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry
- Sunghyouk Park
- College of Pharmacy, Natural Product Research Institute, Seoul National University
- Jae-Ho Cheong
- Department of Surgery, Yonsei University College of Medicine
- Sang Won Kang
- Department of Life Sciences, Research Center for Cell Homeostasis, Ewha Womans University
- Soo-Youl Kim
- Cancer Cell and Molecular Biology Branch, National Cancer Center
- Geum-Sook Hwang
- Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute
- Jong In Yook
- Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry
- Hyun Sil Kim
- Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry
- DOI
- https://doi.org/10.1038/ncomms14374
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Cancer cell survival under metabolic stress is a critical step for metastasis. Here, the authors show that under glucose deprivation, Snail, a key regulator of the metastatic process, promotes survival by diverting glucose to the pentose phosphate pathway through repression of phosphofructokinase PFKP.
