International Journal of General Medicine (Apr 2024)

Association Analysis Between Maternal Neutrophil Ratio and the Risk of Histological Chorioamnionitis in Pregnant Women with Premature Rupture of Membranes in Late Pregnancy

  • Lv Y,
  • Huang Z,
  • Ma Y

Journal volume & issue
Vol. Volume 17
pp. 1499 – 1508

Abstract

Read online

Yan Lv, Zheren Huang, Yan Ma Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of ChinaCorrespondence: Yan Ma, Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of China, Tel +86-0-13813693377, Email [email protected]: We aimed to investigate the association between maternal neutrophil ratio and histological chorioamnionitis (HCA) risk in pregnant women with premature rupture of membranes (PROM) in late pregnancy.Methods: A retrospective analysis was conducted on 95 cases of women with PROM in their late pregnancy between March 2018 and August 2021. These women were divided into two groups based on the presence of HCA. General clinical data and laboratory indicators were compared between the two groups. A generalized additive model was used for curve fitting, and a segmented regression model was used to explain further the non-linear relationship between neutrophil ratio and HCA risk.Results: After adjusting for confounding factors, the curve fitting showed a “U”-shaped curve relationship between the neutrophil ratio and the risk of HCA. When the neutrophil ratio was 76.3%, the HCA risk was significantly increased (adjusted OR = 1.339, 95% CI: 1.067– 1.680, P = 0.012). Furthermore, we equally divided the neutrophil ratio into three groups. The risk of HCA was significantly increased in the low-ratio group (OR = 4.292, 95% CI: 1.247– 14.706, P = 0.021) compared with the middle-ratio group, which was used as the reference group. Similarly, the HCA risk of the high-ratio group (OR = 13.145, 95% CI: 1.796– 96.233, P = 0.011) was also significantly enhanced. However, there was no significant difference in HCA risk between the high-ratio and low-ratio groups (OR = 1.182, 95% CI: 0.357– 3.909, P = 0.784).Conclusion: There was a significant “U”-shaped relationship between maternal neutrophil ratio and HCA risk in women with PROM in late pregnancy.Keywords: premature rupture of membranes, late pregnancy, neutrophil ratio, histological chorioamnionitis, non-linear relationship

Keywords