Nature Communications (Jan 2020)

Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice

  • Ke Zhu,
  • Yumei Lai,
  • Huiling Cao,
  • Xiaochun Bai,
  • Chuanju Liu,
  • Qinnan Yan,
  • Liting Ma,
  • Di Chen,
  • Giedrius Kanaporis,
  • Junqi Wang,
  • Luyuan Li,
  • Tao Cheng,
  • Yong Wang,
  • Chuanyue Wu,
  • Guozhi Xiao

DOI
https://doi.org/10.1038/s41467-019-14186-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

Read online

Beta cell dysfunction and reduction in beta cell mass are hallmark events in the pathogenesis of diabetes mellitus. We identify focal adhesion protein Kindlin-2 as a key factor that controls insulin synthesis and secretion and beta cell mass by modulating MafA and beta-catenin proteins in pancreatic beta cells.