Interplay between gut microbiota and the role of microRNA mechanisms, pathways in cardiovascular diseases

Abstract

The microbiota, which includes microorganisms in the human body's skin, mucosal surfaces, and tissues, is a crucial determinant of health. Diet, family history, and the environment can all impact its components. Pathophysiological changes can occur when these components are altered, leading to various health related issues, including cardiovascular diseases (CVDs). The microbiome, or metagenome of the microbiota, is an intricate ecosystem. MicroRNAs (miRNAs), non-coding RNAs, interact with gut microbes to control host gene expression. These specialized RNAs, which are short chain around 22 nucleotides long, can affect gene expression by modulating mRNA degradation and protein levels. These are play numbers of significant role in cardiovascular diseases and are protected from destruction by extracellular vesicles. In future days permanent care may include controlling the gut microbiota composition and targeted therapy against specific miRNA expressions as this topic gains more attention in scientific studies. Potentially, this might pave the better way for more effective therapies for cardiovascular diseases.

Keywords

• Gut microbiota
• MicroRNA
• Cardiovascular diseases
• Humans
• Ecosystems