Frontiers in Neurology (Nov 2023)
The relationship of small vessel disease burden on cerebral and regional brain atrophy rates and cognitive performance over one year of follow-up after transient ischemic attack
- Noaah Reaume,
- Noaah Reaume,
- Noaah Reaume,
- Noaah Reaume,
- Meaghan Reid,
- Meaghan Reid,
- Meaghan Reid,
- Meaghan Reid,
- Meaghan Reid,
- George S. Tadros,
- George S. Tadros,
- George S. Tadros,
- George S. Tadros,
- George S. Tadros,
- Dorothy Chacinski,
- Dorothy Chacinski,
- Dorothy Chacinski,
- Dorothy Chacinski,
- Britney Denroche,
- Britney Denroche,
- Britney Denroche,
- Arooj Aftab,
- Arooj Aftab,
- Pauline Wu,
- Pauline Wu,
- Pauline Wu,
- Pauline Wu,
- Rani Gupta Sah,
- Rani Gupta Sah,
- Rani Gupta Sah,
- Rani Gupta Sah,
- Meng Wang,
- Eric E. Smith,
- Eric E. Smith,
- Eric E. Smith,
- Eric E. Smith,
- Richard Frayne,
- Richard Frayne,
- Richard Frayne,
- Shelagh B. Coutts,
- Shelagh B. Coutts,
- Shelagh B. Coutts,
- Shelagh B. Coutts,
- Shelagh B. Coutts,
- Shelagh B. Coutts,
- Tolulope Sajobi,
- Tolulope Sajobi,
- Stewart Longman,
- Aravind Ganesh,
- Aravind Ganesh,
- Aravind Ganesh,
- Aravind Ganesh,
- Philip A. Barber,
- Philip A. Barber,
- Philip A. Barber,
- Philip A. Barber,
- Philip A. Barber
Affiliations
- Noaah Reaume
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- Noaah Reaume
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- Noaah Reaume
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- Noaah Reaume
- Department of Psychology, University of Calgary, Calgary, AB, Canada
- Meaghan Reid
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- Meaghan Reid
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- Meaghan Reid
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- Meaghan Reid
- Department of Medical Sciences, University of Calgary, Calgary, AB, Canada
- Meaghan Reid
- Department of Radiology, University of Calgary, Calgary, AB, Canada
- George S. Tadros
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- George S. Tadros
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- George S. Tadros
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- George S. Tadros
- Department of Medical Sciences, University of Calgary, Calgary, AB, Canada
- George S. Tadros
- Department of Neurosciences, University of Calgary, Calgary, AB, Canada
- Dorothy Chacinski
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- Dorothy Chacinski
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- Dorothy Chacinski
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- Dorothy Chacinski
- Department of Psychology, University of Calgary, Calgary, AB, Canada
- Britney Denroche
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- Britney Denroche
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- Britney Denroche
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- Arooj Aftab
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- Arooj Aftab
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- Pauline Wu
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- Pauline Wu
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- Pauline Wu
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- Pauline Wu
- Department of Psychology, University of Calgary, Calgary, AB, Canada
- Rani Gupta Sah
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- Rani Gupta Sah
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- Rani Gupta Sah
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- Rani Gupta Sah
- Department of Radiology, University of Calgary, Calgary, AB, Canada
- Meng Wang
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- Eric E. Smith
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- Eric E. Smith
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- Eric E. Smith
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- Eric E. Smith
- Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
- Richard Frayne
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- Richard Frayne
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- Richard Frayne
- Department of Radiology, University of Calgary, Calgary, AB, Canada
- Shelagh B. Coutts
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- Shelagh B. Coutts
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- Shelagh B. Coutts
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- Shelagh B. Coutts
- Department of Radiology, University of Calgary, Calgary, AB, Canada
- Shelagh B. Coutts
- Department of Neurosciences, University of Calgary, Calgary, AB, Canada
- Shelagh B. Coutts
- Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
- Tolulope Sajobi
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- Tolulope Sajobi
- Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
- Stewart Longman
- Department of Psychology, University of Calgary, Calgary, AB, Canada
- Aravind Ganesh
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- Aravind Ganesh
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- Aravind Ganesh
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- Aravind Ganesh
- Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
- Philip A. Barber
- Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
- Philip A. Barber
- Seaman Family MR Center, Foothills Medical Centre, Calgary, AB, Canada
- Philip A. Barber
- Cumming School of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
- Philip A. Barber
- Department of Radiology, University of Calgary, Calgary, AB, Canada
- Philip A. Barber
- Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
- DOI
- https://doi.org/10.3389/fneur.2023.1277765
- Journal volume & issue
-
Vol. 14
Abstract
BackgroundStroke, even when minor, increases the risk of dementia. We aimed to determine whether patients with transient ischaemic attack (TIA) exhibit higher rates of cerebral and regional atrophy 1-year after first stroke symptoms and evaluate the relationship with small vessel disease and cognitive performance.MethodsTIA patients and controls without cognitive symptoms underwent high-resolution T1-weighted MRI and cognitive testing at baseline and 1-year. Percent brain volume change (PBVC) was measured, and the location of regional atrophy and small vessel disease (CSVD) burden was evaluated. Neuropsychological testing assessed memory, processing speed, and executive function.ResultsA total of 76 TIA patients and 53 controls of mean age 67 (SD = 8) and 68 years (SD = 8) were recruited. TIA patients demonstrated greater improvement of visual memory and executive function at 1-year. TIA patients had greater median PBVC/year compared to controls (−0.79% [(−1.22)-(−0.38)] vs. -0.41% [(−0.62)-0.19]; p < 0.001), and higher rates of volume loss (ml/year) in subcortical gray (−0.53 [(−1.09)-(−0.06)] vs. -0.13 [(−0.61)-0.31]; p < 0.05) and white matter (−2.21 [−5.47, 0.40] vs. -0.93 [(−3.43)-2.10]; p < 0.05). Linear regression showed that TIA, age, and systolic blood pressure (SBP) were associated with greater cerebral volume loss over 1-year. There was no significant relationship between PBVC and 1-year cognition.ConclusionA near two-fold increase in rate of cerebral atrophy 1-year after TIA is associated with higher SBP emphasizing the need for improved treatment of SBP. Cerebral and regional atrophy rates may be used to select patients for vascular risk reduction trials or novel therapeutics in future dementia prevention trials.
Keywords
- brain atrophy
- transient ischaemic attack
- cerebral small vessel disease
- cognitive profiles
- magnetic resonance imaging
