Nature Communications (Sep 2018)
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
- Elena Schmidt,
- Ines Dhaouadi,
- Isabella Gaziano,
- Matteo Oliverio,
- Paul Klemm,
- Motoharu Awazawa,
- Gerfried Mitterer,
- Eduardo Fernandez-Rebollo,
- Marta Pradas-Juni,
- Wolfgang Wagner,
- Philipp Hammerschmidt,
- Rute Loureiro,
- Christoph Kiefer,
- Nils R. Hansmeier,
- Sajjad Khani,
- Matteo Bergami,
- Markus Heine,
- Evgenia Ntini,
- Peter Frommolt,
- Peter Zentis,
- Ulf Andersson Ørom,
- Jörg Heeren,
- Matthias Blüher,
- Martin Bilban,
- Jan-Wilhelm Kornfeld
Affiliations
- Elena Schmidt
- Max Planck Institute for Metabolism Research
- Ines Dhaouadi
- Max Planck Institute for Metabolism Research
- Isabella Gaziano
- Max Planck Institute for Metabolism Research
- Matteo Oliverio
- Max Planck Institute for Metabolism Research
- Paul Klemm
- Max Planck Institute for Metabolism Research
- Motoharu Awazawa
- Max Planck Institute for Metabolism Research
- Gerfried Mitterer
- Department of Laboratory Medicine, Medical University of Vienna
- Eduardo Fernandez-Rebollo
- Department for Biochemistry and Molecular Biology (BMB), University of Southern Denmark
- Marta Pradas-Juni
- Max Planck Institute for Metabolism Research
- Wolfgang Wagner
- Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School
- Philipp Hammerschmidt
- Max Planck Institute for Metabolism Research
- Rute Loureiro
- Max Planck Institute for Metabolism Research
- Christoph Kiefer
- Department for Biochemistry and Molecular Biology (BMB), University of Southern Denmark
- Nils R. Hansmeier
- Max Planck Institute for Metabolism Research
- Sajjad Khani
- Max Planck Institute for Metabolism Research
- Matteo Bergami
- Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD)
- Markus Heine
- Institute for Biochemistry and Molecular Cell Biology
- Evgenia Ntini
- Max Planck Institute for Molecular Genetics
- Peter Frommolt
- Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD)
- Peter Zentis
- Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-associated Diseases (CECAD)
- Ulf Andersson Ørom
- Institute for Molecular Biology and Genetics, Aarhus University
- Jörg Heeren
- Institute for Biochemistry and Molecular Cell Biology
- Matthias Blüher
- Department of Medicine, University of Leipzig
- Martin Bilban
- Department of Laboratory Medicine, Medical University of Vienna
- Jan-Wilhelm Kornfeld
- Max Planck Institute for Metabolism Research
- DOI
- https://doi.org/10.1038/s41467-018-05933-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Brown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure.
