Nature Communications (Oct 2016)
Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch
Abstract
TRPV1 channels are known to mediate pathological pain and itch. Here, the authors find a naturally occurring fatty acid, oleic acid, acts as a TRPV1 antagonist and can modulate capsaicin and histamine-mediated pain and itch response in mouse models.