Nature Communications (Oct 2016)

Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch

  • Sara L. Morales-Lázaro,
  • Itzel Llorente,
  • Félix Sierra-Ramírez,
  • Ana E. López-Romero,
  • Miguel Ortíz-Rentería,
  • Barbara Serrano-Flores,
  • Sidney A. Simon,
  • León D. Islas,
  • Tamara Rosenbaum

DOI
https://doi.org/10.1038/ncomms13092
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

TRPV1 channels are known to mediate pathological pain and itch. Here, the authors find a naturally occurring fatty acid, oleic acid, acts as a TRPV1 antagonist and can modulate capsaicin and histamine-mediated pain and itch response in mouse models.