Nature Communications (Dec 2020)
HIF1A signaling selectively supports proliferation of breast cancer in the brain
- Richard Y. Ebright,
- Marcus A. Zachariah,
- Douglas S. Micalizzi,
- Ben S. Wittner,
- Kira L. Niederhoffer,
- Linda T. Nieman,
- Brian Chirn,
- Devon F. Wiley,
- Benjamin Wesley,
- Brian Shaw,
- Edwin Nieblas-Bedolla,
- Lian Atlas,
- Annamaria Szabolcs,
- Anthony J. Iafrate,
- Mehmet Toner,
- David T. Ting,
- Priscilla K. Brastianos,
- Daniel A. Haber,
- Shyamala Maheswaran
Affiliations
- Richard Y. Ebright
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Marcus A. Zachariah
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Douglas S. Micalizzi
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Ben S. Wittner
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Kira L. Niederhoffer
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Linda T. Nieman
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Brian Chirn
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Devon F. Wiley
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Benjamin Wesley
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Brian Shaw
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Edwin Nieblas-Bedolla
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Lian Atlas
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Annamaria Szabolcs
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Anthony J. Iafrate
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Mehmet Toner
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- David T. Ting
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Priscilla K. Brastianos
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Daniel A. Haber
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Shyamala Maheswaran
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-020-20144-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
The mechanisms underlying the growth of breast cancer metastasis in the brain are unclear. Here, the authors use an intracranial injection mouse model and single-cell analysis of patient circulating tumour cells to demonstrate that increased hypoxic and HIF1A signalling promotes tumour growth in the brain.
