Clinical Ophthalmology (May 2024)

Dry Eye and Some Related Factors in Patients with Type 2 Diabetic Nephropathy: A Cross-Sectional Study in Vietnam

  • Tran Tat T,
  • Ngo Duc K,
  • Pham Hong P,
  • Nguyen Sa H,
  • Nguyen Trung K,
  • Nguyen Thi Thu H,
  • Le Ha K,
  • Nguyen Huu D,
  • Thai Doan T,
  • Le Viet T

Journal volume & issue
Vol. Volume 18
pp. 1217 – 1224

Abstract

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Thang Tran Tat,1 Ky Ngo Duc,2 Phuong Pham Hong,3 Huynh Nguyen Sa,1 Kien Nguyen Trung,4 Ha Nguyen Thi Thu,5 Khoa Le Ha,6 Dung Nguyen Huu,7 Thang Thai Doan,8 Thang Le Viet5 1Department of Cornea and Conjunctiva, Nghe An Eye Hospital, Nghe An, Vietnam; 2Department of Endocrinology, Nghe An Friendship General Hospital, Nghe An, Vietnam; 3Department of Cardiology, Nghe An Friendship General Hospital, Nghe An, Vietnam; 4Hematology and Blood Transfusion Center, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam; 5Organ Transplantation Center, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam; 6Hanoi Medical University, Ha Noi, Vietnam; 7Hemodialysis Center, Bach Mai Hospital, Ha Noi, Vietnam; 8Department of Epidemiology, TTH Vinh General Hospital, Nghe An, VietnamCorrespondence: Thang Le Viet, Military Hospital 103, Vietnam Military Medical University, 261 Phung Hung, Ha Dong, Ha Noi, Vietnam, Tel +84982249968, Email [email protected]: To determine the prevalence of dry eye (DE) and some related factors in patients with type 2 diabetic nephropathy (T2DN).Methods: We performed a cross-sectional study on 338 people, who were divided into 2 groups: 169 T2DN patients and 169 patients diagnosed with type 2 diabetic mellitus (T2DM) without renal complications as a control group. The Ocular Surface Disease Index (OSDI) and test fluorescein tear-film break-up time (TBUT) were done in all 338 subjects. Patients with OSDI scores < 13 and TBUT values equal to or under 10 seconds were diagnosed with dry eye.Results: The prevalence of DE in T2DN patients was significantly higher than T2DM group (55.6% versus 37.3%). The T2DN groups with dry eye had a median duration of DM, the proportion of hypertension, peripheral nerve complications, anemia, proportion of using insulin, and concentration of plasma glucose, HbA1C, urea, creatinine, CRP-hs significantly higher than those of T2DN without dry eye. Advanced age, high HbA1C level, and decreased eGFR were independent factors associated with dry eye in T2DN patients.Conclusion: Dry eye was a common condition associated with advanced age, high HbA1C levels, and decreased GFR in T2DN patients.Keywords: type 2 diabetic nephropathy, dry eye, glomerular filtration rate, hemoglobin A1C

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