Drug repositioning of polaprezinc for bone fracture healing

Eun Ae Ko; Yoo Jung Park; Dong Suk Yoon; Kyoung-Mi Lee; Jihyun Kim; Sujin Jung; Jin Woo Lee; Kwang Hwan Park

doi:10.1038/s42003-022-03424-7

Communications Biology (May 2022)

Drug repositioning of polaprezinc for bone fracture healing

Eun Ae Ko,
Yoo Jung Park,
Dong Suk Yoon,
Kyoung-Mi Lee,
Jihyun Kim,
Sujin Jung,
Jin Woo Lee,
Kwang Hwan Park

Affiliations

Eun Ae Ko: Department of Orthopaedic Surgery, Yonsei University College of Medicine
Yoo Jung Park: Department of Orthopaedic Surgery, Yonsei University College of Medicine
Dong Suk Yoon: Department of Orthopaedic Surgery, Yonsei University College of Medicine
Kyoung-Mi Lee: Department of Orthopaedic Surgery, Yonsei University College of Medicine
Jihyun Kim: Department of Orthopaedic Surgery, Yonsei University College of Medicine
Sujin Jung: Department of Orthopaedic Surgery, Yonsei University College of Medicine
Jin Woo Lee: Department of Orthopaedic Surgery, Yonsei University College of Medicine
Kwang Hwan Park: Department of Orthopaedic Surgery, Yonsei University College of Medicine

DOI: https://doi.org/10.1038/s42003-022-03424-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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Polaprezinc promoted both osteoblast and osteoclast differentiation and altered YAP protein expression in vitro, and animals treated with polaprezinc showed greater bone formation in their fracture calluses after 21 days.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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