Nature Communications (Oct 2020)

Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation

  • Marco Napoli,
  • Xiaobo Li,
  • Hayley D. Ackerman,
  • Avani A. Deshpande,
  • Ivan Barannikov,
  • Marlese A. Pisegna,
  • Isabelle Bedrosian,
  • Jürgen Mitsch,
  • Philip Quinlan,
  • Alastair Thompson,
  • Kimal Rajapakshe,
  • Cristian Coarfa,
  • Preethi H. Gunaratne,
  • Douglas C. Marchion,
  • Anthony M. Magliocco,
  • Kenneth Y. Tsai,
  • Elsa R. Flores

DOI
https://doi.org/10.1038/s41467-020-18973-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Mutations in TP53 and hyperactivation of the PI3K/AKT pathway are the two most frequent drivers of cancer progression across multiple human tumour types. Here, the authors identify two TAp63 regulated long non-coding RNAs, TROLL-2 and TROLL-3, that connect these oncogenic pathways, thus promoting tumour and metastasis formation in a wide variety of cancer types.