Nature Communications (Nov 2020)
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
- Valgerdur Steinthorsdottir,
- Ralph McGinnis,
- Nicholas O. Williams,
- Lilja Stefansdottir,
- Gudmar Thorleifsson,
- Scott Shooter,
- João Fadista,
- Jon K. Sigurdsson,
- Kirsi M. Auro,
- Galina Berezina,
- Maria-Carolina Borges,
- Suzannah Bumpstead,
- Jonas Bybjerg-Grauholm,
- Irina Colgiu,
- Vivien A. Dolby,
- Frank Dudbridge,
- Stephanie M. Engel,
- Christopher S. Franklin,
- Michael L. Frigge,
- Yr Frisbaek,
- Reynir T. Geirsson,
- Frank Geller,
- Solveig Gretarsdottir,
- Daniel F. Gudbjartsson,
- Quaker Harmon,
- David Michael Hougaard,
- Tatyana Hegay,
- Anna Helgadottir,
- Sigrun Hjartardottir,
- Tiina Jääskeläinen,
- Hrefna Johannsdottir,
- Ingileif Jonsdottir,
- Thorhildur Juliusdottir,
- Noor Kalsheker,
- Abdumadjit Kasimov,
- John P. Kemp,
- Katja Kivinen,
- Kari Klungsøyr,
- Wai K. Lee,
- Mads Melbye,
- Zosia Miedzybrodska,
- Ashley Moffett,
- Dilbar Najmutdinova,
- Firuza Nishanova,
- Thorunn Olafsdottir,
- Markus Perola,
- Fiona Broughton Pipkin,
- Lucilla Poston,
- Gordon Prescott,
- Saedis Saevarsdottir,
- Damilya Salimbayeva,
- Paula Juliet Scaife,
- Line Skotte,
- Eleonora Staines-Urias,
- Olafur A. Stefansson,
- Karina Meden Sørensen,
- Liv Cecilie Vestrheim Thomsen,
- Vinicius Tragante,
- Lill Trogstad,
- Nigel A. B. Simpson,
- FINNPEC Consortium,
- GOPEC Consortium,
- Tamara Aripova,
- Juan P. Casas,
- Anna F. Dominiczak,
- James J. Walker,
- Unnur Thorsteinsdottir,
- Ann-Charlotte Iversen,
- Bjarke Feenstra,
- Deborah A. Lawlor,
- Heather Allison Boyd,
- Per Magnus,
- Hannele Laivuori,
- Nodira Zakhidova,
- Gulnara Svyatova,
- Kari Stefansson,
- Linda Morgan
Affiliations
- Valgerdur Steinthorsdottir
- deCODE genetics/Amgen Inc.
- Ralph McGinnis
- Wellcome Sanger Institute
- Nicholas O. Williams
- Wellcome Sanger Institute
- Lilja Stefansdottir
- deCODE genetics/Amgen Inc.
- Gudmar Thorleifsson
- deCODE genetics/Amgen Inc.
- Scott Shooter
- Wellcome Sanger Institute
- João Fadista
- Department of Epidemiology Research, Statens Serum Institut
- Jon K. Sigurdsson
- deCODE genetics/Amgen Inc.
- Kirsi M. Auro
- Finnish Institute for Health and Welfare
- Galina Berezina
- Scientific Center of Obstetrics, Gynecology and Perinatology
- Maria-Carolina Borges
- MRC Integrative Epidemiology Unit, University of Bristol
- Suzannah Bumpstead
- Wellcome Sanger Institute
- Jonas Bybjerg-Grauholm
- Department for Congenital Disorders, Danish Centre for Neonatal Screening, Statens Serum Institut
- Irina Colgiu
- Wellcome Sanger Institute
- Vivien A. Dolby
- Leeds Institute of Medical Research (LIMR), School of Medicine, University of Leeds
- Frank Dudbridge
- Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine
- Stephanie M. Engel
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill
- Christopher S. Franklin
- Wellcome Sanger Institute
- Michael L. Frigge
- deCODE genetics/Amgen Inc.
- Yr Frisbaek
- Department of Obstetrics and Gynecology, Landspitali University Hospital
- Reynir T. Geirsson
- Department of Obstetrics and Gynecology, Landspitali University Hospital
- Frank Geller
- Department of Epidemiology Research, Statens Serum Institut
- Solveig Gretarsdottir
- deCODE genetics/Amgen Inc.
- Daniel F. Gudbjartsson
- deCODE genetics/Amgen Inc.
- Quaker Harmon
- Epidemiology Branch, National Institute of Environmental Health Sciences
- David Michael Hougaard
- Department for Congenital Disorders, Danish Centre for Neonatal Screening, Statens Serum Institut
- Tatyana Hegay
- Institute of immunology and human genomics, Uzbek Academy of Sciences
- Anna Helgadottir
- deCODE genetics/Amgen Inc.
- Sigrun Hjartardottir
- Department of Obstetrics and Gynecology, Landspitali University Hospital
- Tiina Jääskeläinen
- Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital
- Hrefna Johannsdottir
- deCODE genetics/Amgen Inc.
- Ingileif Jonsdottir
- deCODE genetics/Amgen Inc.
- Thorhildur Juliusdottir
- deCODE genetics/Amgen Inc.
- Noor Kalsheker
- School of Life Sciences, University of Nottingham
- Abdumadjit Kasimov
- Institute of immunology and human genomics, Uzbek Academy of Sciences
- John P. Kemp
- MRC Integrative Epidemiology Unit, University of Bristol
- Katja Kivinen
- Division of Cardiovascular Medicine, University of Cambridge
- Kari Klungsøyr
- Division of Mental and Physical Health, Norwegian Institute of Public Health
- Wai K. Lee
- Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow
- Mads Melbye
- Department of Epidemiology Research, Statens Serum Institut
- Zosia Miedzybrodska
- Division of Applied Medicine, School of Medicine, Medical Sciences, Nutrition and Dentistry, University of Aberdeen
- Ashley Moffett
- Department of Pathology, University of Cambridge
- Dilbar Najmutdinova
- Republic Specialized Scientific Practical Medical Centre of Obstetrics and Gynecology
- Firuza Nishanova
- Republic Specialized Scientific Practical Medical Centre of Obstetrics and Gynecology
- Thorunn Olafsdottir
- deCODE genetics/Amgen Inc.
- Markus Perola
- Finnish Institute for Health and Welfare
- Fiona Broughton Pipkin
- School of Medicine, University of Nottingham
- Lucilla Poston
- Department of Women and Children’s Health, King’s College London
- Gordon Prescott
- Division of Applied Medicine, School of Medicine, Medical Sciences, Nutrition and Dentistry, University of Aberdeen
- Saedis Saevarsdottir
- deCODE genetics/Amgen Inc.
- Damilya Salimbayeva
- Scientific Center of Obstetrics, Gynecology and Perinatology
- Paula Juliet Scaife
- School of Medicine, University of Nottingham
- Line Skotte
- Department of Epidemiology Research, Statens Serum Institut
- Eleonora Staines-Urias
- Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine
- Olafur A. Stefansson
- deCODE genetics/Amgen Inc.
- Karina Meden Sørensen
- The Danish National Biobank, Statens Serum Institut
- Liv Cecilie Vestrheim Thomsen
- Department of Clinical Science, Centre for Cancer Biomarkers CCBIO, University of Bergen
- Vinicius Tragante
- deCODE genetics/Amgen Inc.
- Lill Trogstad
- Department of Infectious Disease Epidemiology and Modelling, Norwegian Institute of Public Health
- Nigel A. B. Simpson
- Division of Womens and Children’s Health, School of Medicine, University of Leeds
- FINNPEC Consortium
- GOPEC Consortium
- Tamara Aripova
- Institute of immunology and human genomics, Uzbek Academy of Sciences
- Juan P. Casas
- Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System
- Anna F. Dominiczak
- Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow
- James J. Walker
- Leeds Institute of Medical Research (LIMR), School of Medicine, University of Leeds
- Unnur Thorsteinsdottir
- deCODE genetics/Amgen Inc.
- Ann-Charlotte Iversen
- Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology (NTNU)
- Bjarke Feenstra
- Department of Epidemiology Research, Statens Serum Institut
- Deborah A. Lawlor
- MRC Integrative Epidemiology Unit, University of Bristol
- Heather Allison Boyd
- Department of Epidemiology Research, Statens Serum Institut
- Per Magnus
- Centre for Fertility and Health, Norwegian Institute of Public Health
- Hannele Laivuori
- Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital
- Nodira Zakhidova
- Institute of immunology and human genomics, Uzbek Academy of Sciences
- Gulnara Svyatova
- Scientific Center of Obstetrics, Gynecology and Perinatology
- Kari Stefansson
- deCODE genetics/Amgen Inc.
- Linda Morgan
- School of Life Sciences, University of Nottingham
- DOI
- https://doi.org/10.1038/s41467-020-19733-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Studies to identify maternal variants associated with preeclampsia have been limited by sample size. Here, the authors meta-analyze eight GWAS of 9,515 preeclamptic women, identifying five variants associated with preeclampsia and showing that genetic predisposition to hypertension is a major risk factor for preeclampsia.
