Preoperative NT‐proBNP Predicts Midterm Outcome After Septal Myectomy

Abstract

Background The prognostic value of N‐terminal pro–brain natriuretic peptide (NT‐proBNP) in patients with hypertrophic cardiomyopathy who underwent septal myectomy has not been well studied. Methods and Results We retrospectively evaluated NT‐proBNP levels in 758 patients (46.1±13.8 years; median follow‐up, 936 days) who underwent septal myectomy in our center between March 2011 and April 2018. The median NT‐proBNP level was 1450.5 (interquartile range 682.6‐2649.5) pg/mL. Overall, 22 (2.9%) patients died during follow‐up; of these, 86.4% were cardiovascular deaths. The 3‐year survival free from all‐cause mortality by tertile was 95.2% (95% CI 91.1% to 97.4%; NT‐proBNP >2080 pg/mL), 98.3% (95% CI 94.6% to 99.5%; NT‐proBNP, 947‐2080 pg/mL), and 99.2% (95% CI, 94.4% to 99.9%; NT‐proBNP <947 pg/mL). The 3‐year survival rate free from cardiovascular mortality by tertiles was 95.2% in the highest tertile, 98.8% in the middle tertile, and 99.2% in the lowest tertile. Cox regression analysis indicated that Ln(NT‐proBNP) was a significantly independent predictor of all‐cause mortality (hazard ratio 2.380, 95% CI 1.356‐4.178, P=0.003) and cardiovascular mortality (hazard ratio 2.788, 95% CI 1.450‐5.362, P=0.002). In addition, concomitant coronary artery bypass grafting for coronary artery disease was also an independent predictor of cardiovascular mortality (hazard ratio 5.178, 95% CI 1.597‐16.789, P=0.006). Conclusions Increased preoperative NT‐proBNP level is a strong predictor of midterm mortality in patients undergoing septal myectomy.

Keywords

• brain natriuretic peptide
• hypertrophic cardiomyopathy
• surgery
• survival