Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure

Zhen Li, BS; Chelsea L. Organ, PhD; Jianming Kang, PhD; David J. Polhemus, PhD; Rishi K. Trivedi, PhD; Thomas E. Sharp, III, PhD; Jack S. Jenkins; Ya-xiong Tao, PhD; Ming Xian, PhD; David J. Lefer, PhD

JACC: Basic to Translational Science (Dec 2018)

Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure

Zhen Li, BS,
Chelsea L. Organ, PhD,
Jianming Kang, PhD,
David J. Polhemus, PhD,
Rishi K. Trivedi, PhD,
Thomas E. Sharp, III, PhD,
Jack S. Jenkins,
Ya-xiong Tao, PhD,
Ming Xian, PhD,
David J. Lefer, PhD

Affiliations

Zhen Li, BS: Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana; Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana
Chelsea L. Organ, PhD: Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana; Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana
Jianming Kang, PhD: Department of Chemistry, Washington State University, Pullman, Washington
David J. Polhemus, PhD: Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana; Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana
Rishi K. Trivedi, PhD: Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana; Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana
Thomas E. Sharp, III, PhD: Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana
Jack S. Jenkins: Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana
Ya-xiong Tao, PhD: Department of Anatomy, Physiology, and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, Alabama
Ming Xian, PhD: Department of Chemistry, Washington State University, Pullman, Washington
David J. Lefer, PhD: Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana; Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana; Address for correspondence: Dr. David J. Lefer, Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, 533 Bolivar Street, Room 408, New Orleans, Louisiana 70112.

Journal volume & issue: Vol. 3, no. 6
pp. 796 – 809

Abstract

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Summary: Cardioprotective effects of H2S have been well documented. However, the lack of evidence supporting the benefits afforded by delayed H2S therapy warrants further investigation. Using a murine model of transverse aortic constriction-induced heart failure, this study showed that delayed H2S therapy protects multiple organs including the heart, kidney, and blood-vessel; reduces oxidative stress; attenuates renal sympathetic and renin-angiotensin-aldosterone system pathological activation; and ultimately improves exercise capacity. These findings provide further insights into H2S-mediated cardiovascular protection and implicate the benefits of using H2S-based therapies clinically for the treatment of heart failure. Key Words: cardiorenal syndrome, exercise tolerance, heart failure, hydrogen sulfide, RAAS

Published in JACC: Basic to Translational Science

ISSN: 2452-302X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-basic-to-translational-science/

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