Investigation of the Endothelial Response of Super Elastic Braided Stent: An Experimental Evaluation

Abstract

Aim: This study aimed to experimentally investigate the vascular biocompatibility of the new super elastic braided stents and ultrasonographically follow up the mid-term outcomes on the blood flow of stent-implanted vessels. Method: After designation of the study steps, stents were implanted into the iliac arteries of two ewes. The preoperative and postoperative blood flow and local findings were noted. The ewes were inspected periodically for abnormal body changes, and the stent-implanted vessels were checked with Doppler ultrasonography. The subjects were sacrificed at six months, and the iliac arteries were examined histopathologically. Results: During follow up an occlusive pattern was not observed in the stent-implanted vessels. The histopathological analysis revealed that both two stent area had no significant neointimal hyperplasia, despite sufficient re-endothelisation at the stent surface. Occlusive or stenotic patterns were not detected in both macroscopic and microscopic findings. Conclusion: According to the mid-term findings, our results show that the new super elastic bare stents have good vascular biocompatibility with high patency rates.

Keywords

• super elastic bare stent
• vascular biocompatibility
• neointimal hyperplasia
• experimental model
• super elastic çıplak stent
• vasküler biyouyumluluk
• neointimal hiperplazi
• deneysel model