生物医学转化 (Jun 2024)

Research progress on immunometabolism regulatory mechanisms of tuberculous granuloma

  • Yang Hua,
  • Ge Baoxue

DOI
https://doi.org/10.12287/j.issn.2096-8965.20240211
Journal volume & issue
Vol. 5, no. 2
pp. 91 – 99

Abstract

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Tuberculosis (TB) remains a significant threat to human health. Tuberculous granuloma is a typical pathological feature of TB and also a "refuge" for Mycobacterium tuberculosis (Mtb) to escape host immune defense and achieve long-term survival and latent infection. Mtb exploits these granulomas to spread and propagate within the body, leading to persistent infections that are difficult to eradicate. The metabolic cascade reactions and metabolites produced by immune cells in the granuloma environment are crucial for disease progression and the induction of protective anti-tuberculosis immunity. Mtb can use its virulence factors to target key host metabolic pathways, resist immune defenses, achieve long-term survival, and promote granuloma progression. This paper discusses the key immunometabolism pathways and the regulation mechanism of Mtbhost interaction in granuloma. It provides insights for developing new tuberculosis prevention and treatment strategies targeting granuloma pathogenesis.

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